乳糖酸阿奇霉素治療小兒支氣管炎的效果觀察

馮宏達(dá)　高翔

摘要：目的 ?觀察乳糖酸阿奇霉素治療小兒支氣管炎的臨床療效。方法 ?選取2018年7月～2019年7月在我院診治的106例小兒支氣管炎患兒為研究對(duì)象，采用隨機(jī)數(shù)字表法分為對(duì)照組和觀察組，各53例。對(duì)照組采用紅霉素治療，觀察組采用乳糖酸阿奇霉素治療，比較兩組臨床治療總有效率、臨床癥狀（咳嗽、濕羅音、氣促、哮鳴音）消失時(shí)間、住院時(shí)間、住院費(fèi)用及臨床不良反應(yīng)。結(jié)果 ?觀察組治療總有效率為94.33%，高于對(duì)照組的81.13%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組咳嗽、濕羅音、哮鳴音消失時(shí)間均短于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組住院時(shí)間、住院費(fèi)用均小于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組不良反應(yīng)發(fā)生率低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 ?乳糖酸阿奇霉素治療小兒支氣管炎療效理想，可在短時(shí)間內(nèi)促進(jìn)臨床癥狀消退，促進(jìn)患兒康復(fù)，進(jìn)一步縮短住院時(shí)間，降低住院費(fèi)用。同時(shí)臨床不良反應(yīng)少，應(yīng)用安全可靠。

關(guān)鍵詞：乳糖酸阿奇霉素;咳嗽;支氣管炎

中圖分類(lèi)號(hào)：R725.6 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?文獻(xiàn)標(biāo)識(shí)碼：A ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?DOI：10.3969/j.issn.1006-1959.2020.18.047

文章編號(hào)：1006-1959（2020）18-0143-02

Observation on the Effect of Azithromycin Lactobionate in the Treatment of Infantile Bronchitis

FENG Hong-da1，GAO Xiang2

（1.Department of Pediatrics，Jiamusi Central Hospital，Jiamusi 154002，Heilongjiang，China;

2.Jiamusi City Health Committee，Jiamusi154002，Heilongjiang，China）

Abstract：Objective ?To observe the clinical efficacy of azithromycin lactobionate in the treatment of infantile bronchitis.Methods ?A total of 106 children with infantile bronchitis who were diagnosed and treated in our hospital from July 2018 to July 2019 were selected as the research objects. They were divided into the control group and the observation group by random number table method， with 53 cases in each group. The control group was treated with erythromycin and the observation group was treated with azithromycin lactobionate. The total effective rate of clinical treatment， clinical symptoms （cough， wet rales， shortness of breath， wheezing） disappearance time， hospitalization time， hospitalization expenses and clinical adverse reactions.Results ?The total effective rate of treatment in the observation group was 94.33%， which was higher than 81.13% in the control group，the difference was statistically significant （P<0.05）;The disappearance time of cough， wet rales， and wheezing in the observation group was shorter than that of the control group，the difference was statistically significant （P<0.05）; the length of hospitalization and hospitalization expenses in the observation group were less than that of the control group，the difference was statistically significant （P<0.05）; The incidence of adverse reactions in the observation group was lower than that in the control group，the difference was statistically significant （P<0.05）.Conclusion ?Azithromycin lactobionate had an ideal effect in the treatment of infantile bronchitis. It could promote the resolution of clinical symptoms in a short time， promote the recovery of the children， further shorten the length of hospitalization， and reduce the cost of hospitalization. At the same time， there were few clinical adverse reactions， and the application was safe and reliable.

Key words：Azithromycin lactobionate;Cough;Bronchitis

小兒支氣管炎（infantile bronchitis）是臨床常見(jiàn)疾病，一般是由于患兒上呼吸道感染、流行性感冒以及病毒性感染引起的并發(fā)癥，也可能由于細(xì)菌引發(fā)感染所致。患兒通常會(huì)伴有呼吸困難、憋喘等癥狀，嚴(yán)重者可能發(fā)生呼吸衰竭、缺氧性腦病，嚴(yán)重影響患兒的健康。臨床通常使用紅霉素治療，但治療周期長(zhǎng)，且部分患者出現(xiàn)嚴(yán)重胃腸道反應(yīng)，療效欠佳[1]。乳糖酸阿奇霉素是一種新型大環(huán)內(nèi)酯類(lèi)抗生素，具有較強(qiáng)的阻礙細(xì)菌轉(zhuǎn)肽作用，抑菌效果明顯，可一定程度縮短治療周期，但其臨床療效及安全性尚存在爭(zhēng)議，有待進(jìn)一步研究[2]。本研究結(jié)合2018年7月～2019年7月在我院診治的106例小兒支氣管炎患兒臨床資料，觀察乳糖酸阿奇霉素治療小兒支氣管炎的臨床效果，現(xiàn)報(bào)道如下。

1資料與方法

1.1一般資料 ?選取2018年7月～2019年7月在佳木斯市中心醫(yī)院診治的106例小兒支氣管炎患兒為研究對(duì)象，采用隨機(jī)數(shù)字表法分為對(duì)照組和觀察組，各53例。……