甘利欣對(duì)腫瘤化療過(guò)程中藥物性肝損害的預(yù)防作用

[摘要] 目的 觀察甘利欣對(duì)化療過(guò)程中藥物性肝損害的預(yù)防作用。方法 將36例選用NP方案化療的腫瘤患者隨機(jī)分為治療組和對(duì)照組，在化療過(guò)程中分別用甘利欣（治療組）和肌苷（對(duì)照組）靜滴，觀察化療前后肝功能的變化。結(jié)果 治療組化療后ALT無(wú)明顯變化，對(duì)照組化療后ALT明顯異常。結(jié)論 甘利欣能預(yù)防化療過(guò)程中的藥物性肝損害。

[關(guān)鍵詞] 甘利欣； 腫瘤； 化療； 藥物性肝損害

[中圖分類號(hào)] R730.53 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1673-9701（2009）13-124-02

Preventive Effect of Glycyrrhizin in the Drug-induced Liver Injury by Chemotherapy of Tumor

YOU Chengsheng XU Changchun GUO Yunxia HUO Hong

Department of Oncology and Hematology，the 401th Hospital of PLA，Qingdao 266100

[Abstract] ObjectiveTo explore the preventive effect of glycyrrhizin in the drug-induced liver injury by chemotherapy of tumor. Methods36 tumor patients who selects the NP plan chemotherapy were randomly divided into two groups. There were 18 cases in treatment group，which treated with diammonium glycyrrhizinate injection，and other 18 cases were in control group，which treated with Inosine injection. The patients in both groups all had observed the change of the liver function after chemotherapy. ResultsAfter chemotherapy，ALT had no obvious changes in treatment group，and ALT was significant increased in control group. There was significant difference between them. ConclusionGlycyrrhizin has markedly effects in preventing liver injury resulting from chemotherapy to tumor patients.

[Key Words]Glycyrrhizinate； Therioma； Chemotherapy； Liver injury

惡性腫瘤常需要多療程化療，化療過(guò)程中常發(fā)生藥物性肝損害，從而影響后續(xù)化療方案的施行[1]。如何預(yù)防藥物性肝損害，是腫瘤化療過(guò)程中比較重要的問(wèn)題，我科自2004年10月～2007年12月應(yīng)用甘利欣（甘草酸二胺注射液）預(yù)防藥物性肝損害，結(jié)果滿意，現(xiàn)報(bào)道如下。

1 材料與方法

1.1 一般資料

在我科2003年10月～2006年12月住院患者中選擇接受NP（NVB＋DDP）方案化療的36例，所有入選對(duì)象均無(wú)酒精性肝炎、病毒性肝炎病史，均為病理檢查明確診斷。36例中非小細(xì)胞肺癌25例，乳腺癌11例；男19例，女17例；年齡41～78歲，中位年齡56歲，按隨機(jī)分配原則分為治療組和對(duì)照組。各組患者性別、年齡、化療前肝功能無(wú)統(tǒng)計(jì)學(xué)差異。入組患者疾病及性別分類情況見(jiàn)表1。

1.2 方法

治療組自化療第1天起每天加用甘利欣注射液（江蘇連云港正大天晴制藥有限公司，國(guó)藥準(zhǔn)字H10940190，規(guī)格：10mL：50mg）150mg靜滴，療程10d；對(duì)照組自化療第一天起加用肌苷400mg靜滴，連用10d。于化療前1天及化療后第14天、28天檢測(cè)各組患者肝功能。

1.3 療效評(píng)定標(biāo)準(zhǔn)

依據(jù)衛(wèi)生部《全國(guó)臨床檢驗(yàn)操作規(guī)程》規(guī)定速率法測(cè)定ALT成人參考值5～40U/L[2]，ALT大于40 U/L為肝損害。……