小兒破傷風應用靜脈丙種球蛋白的免疫力效果觀察

[摘要] 目的 為了進一步提高我院治療小兒破傷風的臨床療效，保障患兒的生命安全，本資料就小兒破傷風應用靜脈丙種球蛋白的免疫力的具體臨床效果進行了淺顯的研究和探討。 方法 將我院在2010年10月～2012年12月期間收治的28例破傷風患兒隨機分為觀察組和對照組，兩組患者均14例、給予對照組患兒采用破傷風抗毒素進行常規治療；給予觀察組患兒在常規治療的基礎上加用靜脈丙種球蛋白進行治療，對兩組患兒的治療效果進行觀察和統計。 結果 兩組患兒在接受治療后，觀察組患兒的治療效果要明顯的優于對照組患兒的治療效果，兩組之間的差異有統計學意義（P<0.05）。 結論 破傷風對患兒自身的免疫功能造成不小的影響，在常規治療的基礎上給予患兒靜脈丙種球蛋白治療小兒破傷風的臨床效果十分顯著，有效的提高了臨床療效，保障了患兒的生命安全，降低了疾病對患兒帶來的痛苦，值得推廣。

[關鍵詞] 小兒；破傷風；靜脈丙種球蛋白；免疫力

[中圖分類號] R722.1 [文獻標識碼] B [文章編號] 2095-0616（2013）13-213-02

Observation on immune effect of intravenous immune globulin in the treatment of pediatric tetanus

GONG Dezhang

Department of Emergency， Guizhou Province People's Hospital， Guiyang 550002， China

[Abstract] Objective To preliminarily study and discuss the specific clinical effect of intravenous immune globulin in the treatment of pediatric tetanus， in order to increase the clinical effect of treatment to the pediatric tetanus and guarantee their life safety. Methods 28 pediatric patients with tetanus treated in this hospital from October 2010 to December 2012 were randomly divided into the observation group and control group， including 14 cases in each group. Pediatric patients in the control group received the routine treatment of tetanus antitoxin； while pediatric patients in the observation group received the routine treatment and intravenous immune globulin. Observed and made statistics for the clinical effect of pediatric patients in two groups. Results After receiving the treatment， the clinical effect in the observation group was significantly better than the one in the control group， with the significant difference （P<0.05）. Conclusion Tetanus has a great impact on the immune function of pediatric patients. Based upon the routine treatment， the intravenous immune globulin will have a significant clinical effect in the treatment to pediatric tetanus， which will significantly increase the clinical effect， guarantee patients' life safety， reduce the pains of disease to them and thus is worthy to be propularized.

[Key words] Pediatrics； Tetanus； Intravenous immune globulin； Immunity

破傷風（tetanus）是指由于破傷風梭菌侵入人體傷口后，在厭氧環境下快速大量的進行生長和繁殖，產生嗜神經外毒素而引起患者全身肌肉強直性痙攣為特點的急性傳染病[1]。小兒由于自身的免疫功能還不夠健全，對外在因素的抵抗能力較弱，因此成為破傷風的高發群體。破傷風不僅對患兒的健康發育和成長造成影響，甚至危及患兒的生命安全，針對這種情況，我院對2010年10月～2012年12月期間收治的28例破傷風患兒分別給予了常規治療和靜脈丙種球蛋白治療，并取得了一定的研究成果，現報道如下。……