王霞飛+卜爽剡+吳永良
[摘要] 目的 觀察銀杏達莫注射液對高血壓合并腎功能不全患者血脂及腎功能的影響。 方法 將我院78例高血壓腎功能不全患者隨機分為對照組(38例)和銀杏達莫組(40例),對照組給予常規降壓,銀杏達莫組在常規降壓基礎上,給予銀杏達莫注射液30 mL,每日1次,療程為3周,觀察兩組患者血壓、血脂、腎功能的變化,記錄其不良反應。結果 銀杏達莫組在降低患者24 h尿蛋白排泄量、BUN、Scr,升高HDL-C、Ccr方面均優于對照組(P<0.05)。結論 銀杏達莫注射液可改善高血壓腎功能不全患者的脂質代謝及腎功能。
[關鍵詞] 銀杏達莫;高血壓;腎功能不全;血脂
[中圖分類號] R277.5 [文獻標識碼] B [文章編號] 1673-9701(2014)02-0033-03
Effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency
WANG Xiafei1 BO Shuangshan1 WU Yongliang2
1.Department of Internal Medicine,the People's Hospital of Dongyang City in Zhejiang Province, Dongyang 322100,China; 2.The Peoples Hosptial of Xinchang County in Zhejiang Province, Xinchang 312500, China
[Abstract] Objective To study the effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency. Methods The hypertension complicated with renal insufficiency patients were recruited and randomly assigned to the control group(38 cases) and the ginkgo leaf extract and dipyridamole group(40 cases). All patients received conventional antihypertensive treatment. but those ni the Ginkgo leaf extract and dipyridamole group received Ginkgo leaf extract and dipyridamole injection 30 mL ivgtt qd additionally. The observation was lasted for 3 weeks. The blood pressure, blood lipid and the indices of the renal functions were observed before and after treatment. Results After 3 weeks of treatment, better effects in reducing the 24 h protein excretion in urine,BUN,Scr and increasing HDL-C,Ccr were obtained in the ginkgo leaf extract and dipyridamole group than in the control group(P<0.05). Conclusion The ginkgo leaf extract and dipyridamole could postpone the progression of CRI,improve the lipid metabolize.
[Key words] Ginkgo leaf extract and dipyridamole; Hypertension; Renal dysfunction; Blood lipid
高血壓是我國最常見的慢性病之一,長期的高血壓可引起腎臟小動脈硬化病,腎小管管壁增厚,管腔變窄,進而繼發腎實質缺血性損害,高血壓已成為導致CRF的主要原因之一。近年來隨著高血壓患者的逐年上升,高血壓導致的腎功能不全患者也呈逐年增加,為此,積極防控高血壓腎損害是非常有必要的。研究顯示,銀杏達莫注射液具有清除自由基、改善微循環和腎血流量等作用[1],臨床主要用于動脈硬化及高血壓所致的冠狀動脈供血不足、腦缺血等[2],但對其逆轉高血壓患者腎損害治療的相關臨床研究較少。因此,基于其藥理作用和文獻研究的基礎上,本研究通過觀察銀杏達莫注射液對高血壓合并腎功能不全患者血脂及腎功能的影響,探討其臨床有效性和安全性,為此類患者的中藥治療提供臨床依據。
1資料與方法
1.1入選標準及排除標準
入選標準:所有入選患者均符合2010版《中國高血壓防治指南》中高血壓的診斷標準[3],且均有10年以上高血壓病病史,并伴有腎功能不全,臨床診斷為原發性高血壓合并腎功能不全。……