銀杏達(dá)莫注射液對(duì)高血壓合并腎功能不全患者血脂及腎功能的影響

王霞飛+卜爽剡+吳永良

[摘要] 目的 觀察銀杏達(dá)莫注射液對(duì)高血壓合并腎功能不全患者血脂及腎功能的影響。 方法 將我院78例高血壓腎功能不全患者隨機(jī)分為對(duì)照組（38例）和銀杏達(dá)莫組（40例），對(duì)照組給予常規(guī)降壓，銀杏達(dá)莫組在常規(guī)降壓基礎(chǔ)上，給予銀杏達(dá)莫注射液30 mL，每日1次，療程為3周，觀察兩組患者血壓、血脂、腎功能的變化，記錄其不良反應(yīng)。結(jié)果 銀杏達(dá)莫組在降低患者24 h尿蛋白排泄量、BUN、Scr，升高HDL-C、Ccr方面均優(yōu)于對(duì)照組（P<0.05）。結(jié)論 銀杏達(dá)莫注射液可改善高血壓腎功能不全患者的脂質(zhì)代謝及腎功能。

[關(guān)鍵詞] 銀杏達(dá)莫；高血壓；腎功能不全；血脂

[中圖分類號(hào)] R277.5 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2014）02-0033-03

Effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency

WANG Xiafei1 BO Shuangshan1 WU Yongliang2

1.Department of Internal Medicine，the People's Hospital of Dongyang City in Zhejiang Province， Dongyang 322100，China； 2.The Peoples Hosptial of Xinchang County in Zhejiang Province， Xinchang 312500， China

[Abstract] Objective To study the effect of ginkgo leaf extract and dipyridamole injection on the renal function and the blood lipid of patients with hypertension complicated with renal insufficiency. Methods The hypertension complicated with renal insufficiency patients were recruited and randomly assigned to the control group（38 cases） and the ginkgo leaf extract and dipyridamole group（40 cases）. All patients received conventional antihypertensive treatment. but those ni the Ginkgo leaf extract and dipyridamole group received Ginkgo leaf extract and dipyridamole injection 30 mL ivgtt qd additionally. The observation was lasted for 3 weeks. The blood pressure， blood lipid and the indices of the renal functions were observed before and after treatment. Results After 3 weeks of treatment， better effects in reducing the 24 h protein excretion in urine，BUN，Scr and increasing HDL-C，Ccr were obtained in the ginkgo leaf extract and dipyridamole group than in the control group（P<0.05）. Conclusion The ginkgo leaf extract and dipyridamole could postpone the progression of CRI，improve the lipid metabolize.

[Key words] Ginkgo leaf extract and dipyridamole； Hypertension； Renal dysfunction； Blood lipid

高血壓是我國(guó)最常見的慢性病之一，長(zhǎng)期的高血壓可引起腎臟小動(dòng)脈硬化病，腎小管管壁增厚，管腔變窄，進(jìn)而繼發(fā)腎實(shí)質(zhì)缺血性損害，高血壓已成為導(dǎo)致CRF的主要原因之一。近年來(lái)隨著高血壓患者的逐年上升，高血壓導(dǎo)致的腎功能不全患者也呈逐年增加，為此，積極防控高血壓腎損害是非常有必要的。研究顯示，銀杏達(dá)莫注射液具有清除自由基、改善微循環(huán)和腎血流量等作用[1]，臨床主要用于動(dòng)脈硬化及高血壓所致的冠狀動(dòng)脈供血不足、腦缺血等[2]，但對(duì)其逆轉(zhuǎn)高血壓患者腎損害治療的相關(guān)臨床研究較少。因此，基于其藥理作用和文獻(xiàn)研究的基礎(chǔ)上，本研究通過(guò)觀察銀杏達(dá)莫注射液對(duì)高血壓合并腎功能不全患者血脂及腎功能的影響，探討其臨床有效性和安全性，為此類患者的中藥治療提供臨床依據(jù)。

1資料與方法

1.1入選標(biāo)準(zhǔn)及排除標(biāo)準(zhǔn)

入選標(biāo)準(zhǔn)：所有入選患者均符合2010版《中國(guó)高血壓防治指南》中高血壓的診斷標(biāo)準(zhǔn)[3]，且均有10年以上高血壓病病史，并伴有腎功能不全，臨床診斷為原發(fā)性高血壓合并腎功能不全。……