沐舒坦聯(lián)合固爾蘇對(duì)新生兒呼吸窘迫綜合征的臨床療效

郭倩

[摘要] 目的 探討沐舒坦聯(lián)合固爾蘇對(duì)新生兒呼吸窘迫綜合征的臨床療效。 方法 將168例新生兒呼吸窘迫綜合征患者分為觀察組和對(duì)照組，觀察組給予沐舒坦聯(lián)合固爾蘇治療，對(duì)照組僅給予固爾蘇治療，觀察兩組患者治療24 h后療效，治療后12 h、24 h、48 h血?dú)庵笜?biāo)及兩組患者癥狀緩解時(shí)間、吸氧時(shí)間和住院時(shí)間。 結(jié)果 兩組患者治療24h后有效率分別為71.4%、39.3%；觀察組患者治療24 h、48 h后PaO2均明顯大于對(duì)照組，而PaCO2均明顯小于對(duì)照組，兩組比較具有顯著性差異（P<0.05）；觀察組患者癥狀緩解時(shí)間、吸氧時(shí)間以及住院時(shí)間均明顯短于對(duì)照組（P<0.05）。 結(jié)論 沐舒坦聯(lián)合固爾蘇治療可以明顯改善新生兒呼吸窘迫綜合征患者的血?dú)庵笜?biāo)，緩解癥狀，效果好于單用固爾蘇治療。

[關(guān)鍵詞] 沐舒坦；固爾蘇；新生兒呼吸窘迫綜合征

[中圖分類號(hào)] R722.1 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2014）02-0039-02

Effect of ambroxol combined with curosurf in treatment of neonatal respiratory distress syndrome

GUO Qian

Department of Pediatrics， Linquan People's Hospital in Anhui Province， Linquan 410013， China

[Abstract] Objective To investigate the the clinical curative effect on neonatal respiratory distress syndrome by ambroxol and curosurf together. Methods A total of 168 cases of neonatal respiratory distress syndrome were divided into the observation group and the control group， the observation group was given ambroxol and curosurf treatment， while the control group was treated only with curosurf treatment， curative effect after treatment of 24 h， 12 h， 24 h， 48 h blood gas index and two groups of patients symptoms time， oxygen time and the hospitalization time were observed. Results The efficiency treated after 24 h of two groups were 71.4%，39.3%； PaO2 of the observation group treated after 24 h， 48 h were significantly higher than the control group， while PaCO2 was significantly lower than that of the control group， with significant difference（P<0.05）， the symptoms time， oxygen time and hospital time of the observation group patients was significantly less than that of the control group（P<0.05）. Conclusion Ambroxol and curosurf treatment can obviously improve the blood gas indexes in patients with neonatal respiratory distress syndrome， having a good effect than single using of curosurf.

[Key words] Ambroxol； Curosurf； Neonatal respiratory distress syndrome

新生兒呼吸窘迫綜合征（Neonatal respiratory distress syndrome，NRDS），即肺透明膜病（HMD），是一種以呼氣末肺泡萎陷為特征的特發(fā)性疾病，主要由缺乏肺泡表面活性物質(zhì)（Ps）引起[1]。該疾病常見于早產(chǎn)兒，是導(dǎo)致早產(chǎn)兒死亡的主要原因之一。臨床上主要表現(xiàn)為進(jìn)行性呼吸困難及呼吸衰竭。近年來，隨著越來越多早產(chǎn)兒的降生，如何防治該病成為臨床工作人員的責(zé)任，本研究主要針對(duì)這一問題進(jìn)行了探討。

1資料與方法

1.1一般資料

選取2012年4月～2013年3月本院新生兒病房收治的NRDS患兒168例，其中男96例，女72例，平均胎齡（30.6±2.0）周，平均體重（2050±200）g；所有患兒入院時(shí)均有呼氣性呻吟、呼吸困難、吸氣三凹征和發(fā)紺等癥狀。將168例患者隨機(jī)分為觀察組和對(duì)照組，觀察組84例，男48例，女36例，平均胎齡（30.8±2.2）周，平均體重（2070±210）g；對(duì)照組84例，男48例，女36例，平均胎齡（30.4±1.8）周，平均體重（2030±206）g。兩組患者在性別、胎齡、體重、病情等方面比較無顯著性差異，具有可比性。

1.2方法endprint