
[摘要]目的 探析重組人促紅細胞生成素聯合蔗糖鐵治療腫瘤相關性貧血的臨床效果。方法 方便選取該院2013年5月—2016年5月收治的88例腫瘤相關性貧血患者,隨機將其分為研究組和對照組,研究組采取重組人促紅細胞生成素聯合蔗糖鐵治療,對照組采取單用重組人促紅細胞生成素治療,比較兩組有效率、治療前后血紅蛋白、紅細胞水平及KPS評分。結果 研究組有效率81.82%與對照組45.45%比較差異有統計學意義,P<0.05;治療后,研究組血紅蛋白升高10 g/L、紅細胞升高0.5×1012 g/L、KPS評分升高10分與對照組比較差異有統計學意義,P<0.05。結論 重組人促紅細胞生成素聯合蔗糖鐵治療腫瘤相關性貧血的臨床效果確切,明顯改善血紅蛋白水平,減少輸血次數,延長生存期,值得臨床推廣。
[關鍵詞] 重組人紅細胞生成素;蔗糖鐵;腫瘤;貧血
[中圖分類號] R692 [文獻標識碼] A [文章編號] 1674-0742(2016)11(a)-0152-03
[Abstract] Objective Clinical effect of recombinant human erythropoietin combined with sucrose iron in the treatment of tumor associated anemia. Methods Convenient selected in our hospital in May 2013 to May 2016 88 cases of cancer-related anemia patients randomly the into the study group the control group. study group. take recombinant human erythropoietin generation) combined with iron sucrose treatment, while the control group adopted the single with recombinant human erythropoietin treatment, compared two groups of efficiency, treatment before and after the hemoglobin, red blood cell levels and KPS score. Results Study group, the effective rate was81.82% and control group45.45% and there was significant difference between(P < 0.05). After treatment, hemoglobin in the study group increased 10 g/L, red blood cells elevated 0.5×1012 g/L, KPS score increased 10 points and control group differences are significant, P<0.05. Conclusion Clinical effect of recombinant human erythropoietin combined with sucrose iron in the treatment of tumor associated anemia is exact, significantly improve the hemoglobin level, reduce the number of blood transfusions, prolong the survival period, it is worth clinical promotion.
[Key words] Recombinant human erythropoietin; Sucrose; Tumor; Anemia
腫瘤相關性貧血是臨床腫瘤患者比較常發的并發癥之一,其患病率約90%,促紅細胞生成素屬于一種含有唾液酸的糖蛋白,由165個氨基酸組成,且與內源性紅細胞生成素的作用相同,能夠促使骨髓紅細胞的分化及增值,臨床上用于治療腫瘤相關性貧血,能夠很好的改善患者貧血癥狀,此外,腫瘤患者常常也發生缺鐵的癥狀,缺鐵比較嚴重的話,對紅細胞生成素的治療也形成一定的影響,因此,需聯合鐵劑同時治療[1]。為探析重組人促紅細胞生成素聯合蔗糖鐵治療腫瘤相關性貧血的臨床效果,該文將2013年5月—2016年5月收治的88例腫瘤相關性貧血患者,作為研究對象,現報道如下。……