奧沙利鉑聯(lián)合亞葉酸鈣、替加氟治療中晚期胃癌的臨床分析

[摘要] 目的 討論分析中晚期胃癌病人運(yùn)用奧沙利鉑聯(lián)合亞葉酸鈣和替加氟化療的臨床治療效果。 方法 整群選取2010年12月—2014年5月期間該院收治的158例中晚期胃癌病人作為研究對(duì)象，將158例病人隨機(jī)分成兩組，一組分為治療組79例病人，一組分為對(duì)照組79例病人。對(duì)照組中的79例病人在化療時(shí)采用奧沙利鉑、亞葉酸鈣以及5-氟尿嘧啶進(jìn)行治療，治療組中的79例病人在化療時(shí)采用奧沙利鉑、亞葉酸鈣以及替加氟進(jìn)行治療。統(tǒng)計(jì)分析兩組病人的臨床治療效果，并將統(tǒng)計(jì)好的臨床治療效果數(shù)據(jù)進(jìn)行組間對(duì)比。結(jié)果 在統(tǒng)計(jì)分析兩組病人臨床治療效果數(shù)據(jù)的比對(duì)結(jié)果中，治療組79例病人總體有效率為73.41%；對(duì)照組79例病人總體有效率為50.63%；兩組病人臨床治療效果的相關(guān)數(shù)據(jù)在進(jìn)行組間對(duì)比時(shí)，兩組數(shù)據(jù)的差異有統(tǒng)計(jì)學(xué)意義（P<0.05），符合統(tǒng)計(jì)時(shí)運(yùn)用的統(tǒng)計(jì)學(xué)的基本內(nèi)容。結(jié)論 治療組病人的總體治療有效率明顯高于對(duì)照組，且兩組不良反應(yīng)相似，主要表現(xiàn)為神經(jīng)毒性、惡心嘔吐、粘膜炎、骨髓抑制等。因此該文研究中的奧沙利鉑聯(lián)合亞葉酸鈣、替加氟治療中晚期胃癌，能大幅度提高病人的臨床治療有效率，不良反應(yīng)少，在臨床中，值得推廣與應(yīng)用。

[關(guān)鍵詞] 奧沙利鉑；亞葉酸鈣；替加氟；中晚期胃癌；臨床分析

[中圖分類(lèi)號(hào)] R735 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-0742（2016）11（a）-0113-03

[Abstract] Objective The discussion and analysis of clinical therapeutic effect of advanced oxaliplatin combined with calcium folinate and tegafur with chemotherapy in patients with gastric cancer. Methods Group selection December 2010 to Macy 2014 in our hospital during the period of 158 cases of advanced gastric cancer patients was selected as the object of study， 158 cases of patients were randomly divided into two groups， were divided into the treatment group of 79 patients， a group divided into the control group of 79 patients. The control group of 79 patients on chemotherapy using oxaliplatin， leucovorin calcium and fluorouracil for treatment， the treatment group of 79 patients in the chemotherapy using oxaliplatin， calcium folinate and tegafur treatment. Statistical analysis of the two groups of patients with clinical treatment effect， and statistical good clinical treatment effect data for group comparison. Results In the statistical analysis of the comparison of two groups of patients clinical data on the effect of the treatment group （n = 79） patients overall efficacy rate was 73.41%； control group （79 cases） patients overall efficacy rate was 50.63%； the relevant data of the clinical therapeutic effect of two groups of patients in the comparison between the two groups， the difference of two groups of data significantly （P < 0.05）， in line with the statistics of the application of statistics. Conclusion Treatment patient group total effective rate of the treatment group was significantly higher than that in the control group， and adverse reactions of the two groups were similar， mainly for neurotoxicity， nausea and vomiting， mucositis， bone marrow suppression. Therefore this study with oxaliplatin combined with calcium， for tegafur in the treatment of advanced gastric cancer， can greatly improve the patient's clinical treatment efficiency， with less adverse reactions. In clinic， it is worth popularization and application

[Key words] Oxaliplatin； Calcium calcium； For the addition of fluoride； Advanced gastric cancer； Clinical analysis

由于健康生活的認(rèn)知沒(méi)有引起人們的關(guān)注，從而導(dǎo)致人們?cè)谌粘Ｉ钪械牟涣剂?xí)慣越來(lái)越多，從而引發(fā)諸多疾病問(wèn)題；尤其是人們的不良飲食習(xí)慣引起的消化系統(tǒng)疾病，比如胃癌，大多數(shù)就診時(shí)已為中晚期，在治療時(shí)，治療難度大，且往往沒(méi)有治愈的可能性。……