[摘要] 目的 探討多環黏膜切除術治療早期食管癌及癌前病變的臨床療效。 方法 該文方便選取了該院2011年1月—2013年12月間入院經過多環黏膜切除術治療的45例早期食管癌及癌前病變患者為研究對象,針對治療效果進行了分析及隨訪。 結果 45例患者全部成功進行病灶切除。鱗狀細胞上皮中度不典型增生4例,鱗狀細胞上皮重度不典型增生30例,原位癌6例,黏膜內癌5例。術后出血1例,占2.2%,經胃鏡下止血成功;術后出現食管狹窄2例,占4.4%,經胃鏡下擴張術后狹窄得到緩解;3例出現復發及殘留,復發殘留率6.7%。結論 多環粘膜切除術是治療早期食管癌及癌前病變簡單、有效的方法。
[關鍵詞] 多環粘膜切除術;早期食管癌;癌前病變
[中圖分類號] R735.1 [文獻標識碼] A [文章編號] 1674-0742(2016)11(a)-0014-03
[Abstract] Objective The Clinical therapeutic efficacy of endoscopic multiband mucosectomy(MBM) for early esophageal cancer and precancerous lesions was evaluated after treatment. Methods Convenient selection from January 2011 to December 2013,45 patients were treated with MBM in the hospital. Observation was conducted on the therapeutic efficacy and the complication of MBM. Results Lesions were resected successfully for all the 45 cases.There are 4 moderate Dysplasia of squamous cell,30 Severe Dysplasia of squamous cell,6 Carcinoma in situ and 5 intra-mucosal carcinoma in all patients.1cases of hemorrhage (2.2%) occured after the operations, for which hemostasia was successfully achived by endoscopy. Esophageal stenosis existed in another 2 cases(4.4%),for which stenosis was relieved by endoscopic therapy.Remain and recurrence was present in 3 cases(6.7%). Conclusion The treatment with MBM is easy and effective for early esophageal cancer and precancerous lesions.
[Key words] Multiband mucosectomy;Early esophageal cancer;Precancerous lesions
早期食管癌(Early esophageal cancer)是指癌變局限于粘膜層及粘膜下層,并無淋巴結轉移。早期食管癌一般無明顯癥狀,多在內鏡檢查時偶然發現,并且其術后5 年生存率可達到90% 以上[1]。近年來,消化內鏡技術的飛速發展已經大大提高了內鏡診斷和治療早期食管癌(Early esophageal cancer)及癌前病變(Precancerous lesions)的能力。其中,內鏡下多環粘膜切除術(multiband mucosectomy,MBM)治療早期食管癌和癌前病變的內鏡治療技術已被越來越多的內鏡醫生接受。該文對該院2011年10月—2013年12月收治的45例MBM早期食管癌和癌前病變進行回顧性研究,通過分析其切除率、并發癥和復發率評價MBM對早期食管癌和癌前病變的臨床價值,報道如下。
1 資料與方法
1.1 一般資料
方便選取該組病例總數45例,男31例,女14例,年齡42~78歲,平均57歲。……