干擾素治療復(fù)發(fā)緩解型多發(fā)性硬化的有效性研究

[摘要] 目的 對(duì)復(fù)發(fā)緩解型多發(fā)性硬化治療中干擾素的有效性進(jìn)行分析探討。方法 方便選取于該院治療復(fù)發(fā)緩解型多發(fā)性硬化的病患120例，將其作為研究對(duì)象并隨機(jī)均等分為實(shí)驗(yàn)組和對(duì)照組，每組各60例。對(duì)對(duì)照組使用地塞米松進(jìn)行治療，實(shí)驗(yàn)組則在此基礎(chǔ)上使用干擾素β進(jìn)行治療。對(duì)兩組病患治療前、治療3個(gè)月之后、治療6個(gè)月之后的ADL（日常生活活動(dòng)量表）及NDS（神經(jīng)功能缺損程度）進(jìn)行評(píng)分并比對(duì)。 結(jié)果 經(jīng)治療6個(gè)月后，實(shí)驗(yàn)組ADL評(píng)分（60.52±10.47）分顯著高于對(duì)照組（51.64±10.71）分，NDS評(píng)分（12.29±2.43）分顯著低于對(duì)照組（15.31±3.98）分，P<0.05，差異具有統(tǒng)計(jì)學(xué)意義。結(jié)論 對(duì)復(fù)發(fā)型多發(fā)性硬化病患使用β干擾素進(jìn)行治療能夠有效改善病患的神經(jīng)功能，使病患的復(fù)發(fā)概率顯著下降。

[關(guān)鍵詞] 干擾素；復(fù)發(fā)緩解型；多發(fā)性硬化

[中圖分類號(hào)] R744.51 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-0742（2016）11（a）-0126-03

[Abstract] Objective To analyze the efficacy of interferon in the treatment of recurrent and multiple sclerosis.Methods Convenient selection from August 2015 to July 2016， 120 cases of patients with multiple sclerosis in our hospital were selected as the study subjects and randomly divided into experimental group and control group， 60 cases in each group. The control group was treated with dexamethasone， and the experimental group was treated with interferon beta. The two groups of patients before treatment， 3 months after treatment， 6 months after the treatment of ADL（daily living activity scale） and NDS （nerve function defect degree） were scored and compared. Results After 6 months of treatment， the experimental group ADL score （60.52 ±10.47）points was significantly higher than that of the control group （51.64 ± 10.71）points， NDS （12.29 ± 243） points was significantly lower than that of the control group （15.31 ± 3.98）points， P < 0.05， the data can be statistically significant. Conclusion It is effective to improve the neurological function of patients with multiple sclerosis by using beta interferon， which can significantly decrease the recurrence rate of patients with multiple sclerosis.

[Key words] Interferon；Relapse remission type；Multiple sclerosis

復(fù)發(fā)緩解型多發(fā)性硬化是一種常見于臨床的中樞神經(jīng)系統(tǒng)疾病，多發(fā)人群為中青年。主要病理特征為神經(jīng)元丟失、軸突變性、脫髓鞘、炎癥等，主要臨床表現(xiàn)為反復(fù)進(jìn)展或發(fā)作，最終致使神經(jīng)功能出現(xiàn)嚴(yán)重?fù)p傷。復(fù)發(fā)緩解型多發(fā)性硬化屬于病程較為遷延的一種免疫性疾病。臨床通常使用地塞米松進(jìn)行治療，但其治療效果并不十分理想。而疾病復(fù)發(fā)率高的特點(diǎn)給病患及其家屬帶來了極為沉重的經(jīng)濟(jì)負(fù)擔(dān)及心理壓力。所以選取高效的治療手段對(duì)疾病治愈有著至關(guān)重要的意義。近年干擾素在復(fù)發(fā)緩解型多發(fā)性硬化中應(yīng)用愈發(fā)廣泛。此次實(shí)驗(yàn)就干擾素在復(fù)發(fā)緩解型多發(fā)性硬化治療中的有效性進(jìn)行分析與探討。……