[摘要] 目的 評定潰瘍性結腸炎伴抑郁的臨床治療及臨床效果。方法 方便選取該院2014年2月—2016年1月收治的60例潰瘍性結腸炎伴抑郁患者為研究對象,隨機分成對照組和觀察組,30例/組。對照組給予美沙拉嗪腸溶片口服治療,觀察組在對照組的治療基礎上給予鹽酸舍曲林片口服治療。觀察2組潰瘍性結腸炎伴抑郁患者治療前后的UCAI、SDS評分、HAMD評分以及臨床療效。結果 觀察組患者治療后的UCAI(67.25±21.54)、SDS評分(47.25±4.34)分、HAMD評分(11.25±5.36)分均優于對照組,P<0.05,2組患者的治療總有效率(觀察組:80.00%,對照組:73.33%)對比差異無統計學意義。結論 美沙拉嗪腸溶片與鹽酸舍曲林片聯合治療潰瘍性結腸炎伴抑郁患者既能保證臨床治療效果,又能改善患者的抑郁癥狀。
[關鍵詞] 美沙拉嗪腸溶片;鹽酸舍曲林片;潰瘍性結腸炎;抑郁
[中圖分類號] R574 [文獻標識碼] A [文章編號] 1674-0742(2016)11(c)-0071-03
[Abstract] Objective To evaluate the clinical treatment of ulcerative colitis associated with depression and clinical effect.Methods Convenient selection our hospital from February 2014 to January 2016, 60 patients with ulcerative colitis associated with depression as the research object, and randomly divided into control group and observation group, 30 cases/group. The control group to give the salad oxazine enteric-coated metformin hydrochloride oral treatment, observation group on the basis of the treatment in the control group given sertraline hydrochloride oral treatment. To observe the two groups before and after treatment in patients with ulcerative colitis associated with depression UCAI, scores of SDS, HAMD scores and clinical curative effect.Results The observation group of patients after treatment of UCAI(67.25±21.54), scores of SDS(47.25±4.34)points and HAMD scores(11.25±5.36)points were better than control group, P <0.05, the treatment of patients with two groups total effective rate (Observation group: 80%, control group: 73.33%)compared with no statistical significance.Conclusion The salad oxazine enteric-coated metformin hydrochloride combined with sertraline hydrochloride tablet to treat ulcerative colitis with depressed patients can not only ensure the clinical therapeutic effect, and can improve the depressive symptoms of patients.
[Key words] The salad oxazine enteric-coated metformin hydrochloride; Sertraline hydrochloride; Ulcerative colitis; Depression
潰瘍性結腸炎屬于慢性非特異性炎性腸疾病,發病部位多為直腸與乙狀結腸部位[1]。治療期間患者可能出現各種并發癥,導致患者產生焦慮、抑郁等負面情緒,嚴重影響治療效果。該文旨在評定潰瘍性結腸炎伴抑郁的臨床治療及臨床效果,以該院2014年2月—2016年1月收治的60例潰瘍性結腸炎伴抑郁為研究對象,現報道如下。
1 資料與方法
1.1 一般資料
研究對象:方便選取該院收治的60例潰瘍性結腸炎伴抑郁患者。隨機分成對照組和觀察組,30例患者為一組。對照組:男:女=18:12;年齡范圍19~64歲,平均年齡(37.24±2.14)歲。觀察組:男:女=17:13;年齡范圍20~66歲,平均年齡(37.14±2.26)歲。2組潰瘍性結腸炎伴抑郁患者的基線資料差異無統計學意義(P>0.05)。……