[摘要] 目的 探討透明質(zhì)酸鈉凝膠在人工流產(chǎn)術(shù)后對宮腔粘連的預防效果。方法 方便選取2015年6—12月在該院進行人工流產(chǎn)手術(shù)患者150例,隨機分為對照組和治療組,每組75例,兩組同時采用同樣的人工流產(chǎn)手術(shù)。對照組患者在術(shù)后給予廣譜抗生素預防感染,治療組術(shù)后注射醫(yī)用透明質(zhì)酸鈉凝膠3 mL,并在術(shù)后給予廣譜抗生素預防感染,然后對兩組患者術(shù)后發(fā)生宮腔粘連的情況進行對比。結(jié)果 對照組患者發(fā)生宮腔粘連的情況為7例,所占比例為9.32%,而治療組僅出現(xiàn)2例,所占比例為2.66%;治療組的微循環(huán)指標,毛細血管流速為(0.32±0.09)mm/s,白色微血栓個數(shù)為(1.03±0.26)個,紅細胞聚集指數(shù)為(1.45±0.54),效果好于對照組的(0.21±0.11)mm/s,(1.67±0.23)個,(0.92±0.33);同時,我們發(fā)現(xiàn)患者陰道出血時間持續(xù)(4.43±1.45)d,月經(jīng)恢復較快為(27.46±3.80)d,低于對照組的(8.86±1.49)d,(36.06±3.42)d。結(jié)論 透明質(zhì)酸鈉凝膠可止血、預防宮腔感染和粘連,其操作簡單,效果顯著,不良反應小,可以在臨床上推廣和使用。
[關(guān)鍵詞] 宮腔粘連;人工流產(chǎn);透明質(zhì)酸鈉凝膠
[中圖分類號] R169 [文獻標識碼] A [文章編號] 1674-0742(2016)11(c)-0118-03
[Abstract] Objective To discuss the effect of sodium hyaluronate gel on the prevention of intrauterine adhesion after induced abortion. Methods Convenient selection from June 2015 to December 2015 150 patients were randomly divided into the control group and the treatment group, 75 cases in each group, and the two groups were treated with the same artificial abortion operation. Patients in the control group were given antibiotics to prevent infection after surgery. After surgery, the treatment group was injected with medical sodium hyaluronate gel 3 mL. Results Control group of patients occurred caused by intrauterine adhesions in 7 cases, accounted for 9.32%,And the treatment group appear only in 2 cases, the proportion is 2.66%;Treatment group of microcirculation, blood capillary flow velocity for (0.32 ± 0.09) mm/s,White micro thrombus was (1.03±0.26),Red blood cell aggregation index was (1.45±0.54),Better than in the control group (0.21 ± 0.11) mm/s, (1.67±0.23), (0.92±0.33);At the same time, we found that patients with vaginal bleeding duration (4.43±1.45) d,Menstruation restore faster (27.46±3.80) d,Lower than the control group (8.86±1.49) d, (36.06±3.42)d. Conclusion Sodium hyaluronate gel can be used to prevent infection and adhesion. Its operation is simple and the effect is obvious, so it can be popularized and used in clinical practice.
[Key words] Intrauterine adhesion;Abortion; Sodium hyaluronate gel
宮腔粘連是指患者子宮腔、宮頸包括子宮峽部的粘連,任何引起子宮內(nèi)膜破壞的因素都可導致宮腔粘連。其中,妊娠有關(guān)的約9l%,常見于進行人工流產(chǎn)。在修復子宮內(nèi)膜的過程中,只要受到感染,宮腔粘連就容易復發(fā),尤其重度患者的復發(fā)率更高[1]。宮腔粘連成為危害育齡期女性身心健康的常見問題[2-3]。因此,尋找一種安全、有效的預防與控制措施一直是臨床的焦點。該文在2015年6—12月在該院進行人工流產(chǎn)手術(shù)的患者術(shù)后應用透明質(zhì)酸鈉凝膠預防宮腔粘連方面取得了積極效果,現(xiàn)報道如下。……