聚乙二醇電解質(zhì)口服溶液用于術(shù)前腸道準(zhǔn)備的有效性及安全性

[摘要] 目的 探討聚乙二醇電解質(zhì)口服溶液用于術(shù)前腸道準(zhǔn)備中的有效性和安全性。方法 方便選取2014年2月—2015年3月該院收治擬行腹腔鏡手術(shù)的80例患者分為對照組和觀察組，對照組給予術(shù)前口服20%甘露醇，觀察組給予術(shù)前口服聚乙二醇電解質(zhì)口服溶液，觀察兩組服藥后的安全性、不良反應(yīng)以及清腸效果。 結(jié)果 與對照組相比，觀察組服藥后安全性明顯較高，不良反應(yīng)發(fā)生率較低（7.5%），P<0.05，差異具有統(tǒng)計學(xué)意義。與對照組相比，觀察組藥物口感好評率（97.5%）、服藥的依從率（100%）明顯較高，P<0.05，差異具有統(tǒng)計學(xué)意義。觀察組清潔率為92.5%；對照組清潔率為62.5%，兩組清潔率相比差異具有統(tǒng)計學(xué)意義（χ2=10.632，P<0.05）。結(jié)論 聚乙二醇電解質(zhì)口服溶液在術(shù)前腸道準(zhǔn)備中具有較高的安全性和可靠性，使用方便，便于術(shù)前的腸道準(zhǔn)備。

[關(guān)鍵詞] 腸道準(zhǔn)備；聚乙二醇電解質(zhì)口服溶液；效果

[中圖分類號] R472 [文獻標(biāo)識碼] A [文章編號] 1674-0742（2016）11（c）-0129-03

[Abstract] Objective To investigate the oral polyethylene glycol electrolyte solution for bowel preparation before surgery in efficacy and safety. Methods Convenient selection February 2014 to March 2015 in our hospital undergoing laparoscopic surgery 80 patients were divided into control group and observation group， the control group received preoperative oral administration of 20% mannitol， observation group received preoperative oral polyethylene diol oral electrolyte solution， observe safety， side effects and after taking two bowel effect. Results Compared with the control group， the observation group was significantly higher medication safety， lower incidence of adverse reactions（7.5%）， P <0.05， the difference was statistically significant. Compared with the control group， the observation group of drugs taste favorable rate（97.5%）， medication compliance（100.0%） was significantly higher， P <0.05， the difference was statistically significant. Clean the observation group was 92.5%； 62.5% in the control group cleaning， cleaning rate between the two groups was statistically significant compared to（χ2 = 10.632，P <0.05）. Conclusion Polyethylene glycol-electrolyte oral solutions with high security and reliability， ease of use in bowel preparation before surgery， to facilitate bowel preparation before surgery.

[Key words] Bowel preparation； Polyethylene glycol oral electrolyte solution； Effect

腸道準(zhǔn)備作為肝膽外科手術(shù)常規(guī)的術(shù)前準(zhǔn)備，腸道的清理效果關(guān)系著術(shù)后感染的控制以及腸道功能的恢復(fù)情況，對減少并發(fā)癥具有直接的影響和作用。傳統(tǒng)機械式術(shù)前腸道準(zhǔn)備操作的過程過于頻繁，且病人耐受性較低，口服一般的清腸藥物效果不佳，容易造成術(shù)后的感染和腸道功能的障礙，對患者造成很大的影響[1]。聚乙二醇電解質(zhì)口服溶液和甘露醇作為術(shù)前腸道準(zhǔn)備最常用的兩種清腸藥物，甘露醇屬于高滲性溶液，患者不良反應(yīng)較多。而聚乙二醇電解質(zhì)口服溶液臨床安全性高，患者依從性好[2]。……