[摘要] 目的 分析脂肪肝和丙肝病毒(HCV)感染之間的影響和具有的相關性。方法 整群選取該院自2015年8月—2016年2月期間收治的165例脂肪肝患者定為觀察組,選取同時期165名體檢情況健康的正常人為對照組,然后對比兩組在HCV感染方面的差異。 結果 觀察組165例患者共檢測出抗HCV陽性19例(11.5%),其中血清標本同時伴有HCVRNA12例(7.3%);均明顯高于對照組,兩組患者的HCV二項指標(抗HCV和HCVRNA)陽性率對比,差異有統計學意義(P﹤0.05)。將19例合并HCV感染的脂肪肝患者,與63例單純脂肪肝患者的HDL-C、AST、及CH、ALT和TG等血清生化指標的情況進行了對比,差異無統計學意義。但是丙肝合并脂肪肝患者的ALT值要高于單純脂肪肝患者。結論 脂肪肝和HCV感染有著十分密切的關系,在一定情況下,HCV感染會引起脂肪肝,而且可以發現,在慢性HCV感染患者發展成為肝硬化的過程中,通常都會經歷脂肪肝這一前期過渡階段,故應當對HCV感染加以控制預防,有著重要的意義。
[關鍵詞] 丙型肝炎;病毒感染;臨床研究;脂肪肝
[中圖分類號] R322.4 [文獻標識碼] A [文章編號] 1674-0742(2016)11(c)-0031-03
[Abstract] Objective Analysis of fatty liver and hepatitis C virus (HCV) infection and the correlation between them. Methods Group selection our hospital from August 2015 to February 2016 were 165 fatty liver patients as the observation group, select the same period 165 cases of healthy physical examination of the normal control group, and then compared the two groups in the different aspects of HCV infection. Results The 165 observation group patients were detected in 19 anti HCV positive cases (11.5%), the serum samples with HCVRNA12(7.3% cases); were significantly higher than the control group, the two indicators of the two groups of patients HCV(anti HCV and HCVRNA) positive rate comparison, there are obvious differences(P < 0.05), with statistical significance , HDL-C, and AST, CH,, ALT and TG serum biochemical indexes of 63 patients with HCV infection were compared with other serum biochemical indexes, the difference was not statistically significant. But hepatitis C patients with nonalcoholic fatty liver ALT values were higher than that of pure fatty liver. Conclusion Fatty liver and HCV infection are closely related, in certain cases, HCV infection can cause fatty liver, and it can be found in patients with chronic HCV infection develop cirrhosis of the liver in the process, usually through the early transition stage of fatty liver, it should be on the prevention and control of HCV infection, a important.
[Key words] Hepatitis C; Viral infection; Clinical study; Fatty liver
近年來,脂肪肝的患病人數日益增多,該病屬于病毒性肝炎引起的一種并發癥。伴隨著在臨床診斷方面普遍應用高分辨率B超與CT,從而獲得了脂肪肝在影像學上特征性改變的新發現,這樣,通過影像學檢查大大提升了診斷準確率,并使得對脂肪肝的診斷有了更可靠的依據[1]。對于脂肪肝的起病原因,一直以來都是認為和下列因素有關:即營養不良、妊娠、糖尿病、以及肥胖、長期酗酒與應用皮質激素等因素[2],對于HCV感染和脂肪肝之間的關系,則研究的很少。……