[摘要] 目的 研究丹參治療蛛網膜下腔出血后腦血管痙攣的治療效果及其機制。方法 方便選取該院2015年5月—2016年5月診治的蛛網膜下腔出血后腦血管痙攣的病人80例,隨機分成實驗組和對照組,每組40例,對照組使用一般的診治方法,實驗組在對照組的基礎上使用丹參注射液進行診治,之后使用放射免疫分析法檢測兩組血漿內皮素的水平。 結果 對照組用藥前血漿內皮素水平為(66.64±14.78)ng/L,發病第3天為(59.67±12.91)ng/L,發病第10天為(56.18±9.27)ng/L;實驗組分別對應的是(65.21±15.55)ng/L,(47.38±10.26)ng/L,(49.58±8.99)ng/L,差異均具有統計學意義, P<0.05。 結論 丹參治療蛛網膜下腔出血后腦血管痙攣有一定效果,值得在臨床當中推廣使用。
[關鍵詞] 丹參;蛛網膜下腔出血;腦缺血;內皮素
[中圖分類號] R277.7 [文獻標識碼] A [文章編號] 1674-0742(2016)11(c)-0142-03
[Abstract] Objective To study the therapeutic effect and mechanism of Salvia miltiorrhiza on cerebral vasospasm after subarachnoid hemorrhage. Methods Convenient selection 80 cases of cerebral vasospasm in our hospital in May 2015 to May 2016 in the diagnosis and treatment of subarachnoid hemorrhage patients were randomly divided into experimental group and control group, 40 cases in each group, the control group used the general methods of diagnosis and treatment, the experimental group used Danshen injection treatment on the basis of the control group, after using radioimmunoassay detection of plasma endothelin levels in the two groups. Results In the control group before treatment, the level of plasma endothelin was (66.64±14.78) ng/L, the incidence of third days(59.67±12.91)ng/L, the incidence of tenth days (56.18±9.27)ng/L; the experimental group corresponding to the (65.21±15.55)ng/L,(47.38±10.26)ng/L,(49.58±8.99)ng/L,differences were statistically significant, P<0.05. Conclusion Salvia miltiorrhiza treatment of cerebral vasospasm after subarachnoid hemorrhage has a certain effect, it is worth popularizing in clinical use.
[Key words] Salvia miltiorrhiza; Subarachnoid hemorrhage; Cerebral ischemia; Endothelin
蛛網膜下腔出血之后的遲發性腦血管痙攣是影響蛛網膜下腔出血病人治療效果以及預后的重要原因之一,目前,臨床當中基本上使用西藥的方法來預防蛛網膜下腔出血之后的遲發性腦血管痙攣的出現,關于使用丹參注射液來預防蛛網膜下腔出血之后的遲發性腦血管痙攣的報道比較少見,使用血漿內皮素作為改變的檢測標準,來測定丹參注射液預防蛛網膜下腔出血之后的遲發性腦血管痙攣的治療效果[1-3]。該文方便選取2015年5月—2016年5月在該院進行診治的蛛網膜下腔出血后腦血管痙攣的病人80例,對照組使用一般的診治方法,實驗組在對照組的基礎上使用丹參注射液進行診治,之后使用放射免疫分析法檢測兩組血漿內皮素的水平,研究丹參治療蛛網膜下腔出血后腦血管痙攣的治療效果及其機制,取得了良好的成績,現報道如下。……