戴列軍 龐洪 黃鐵軍 王海



【摘要】目的:研究男性慢性肝病患者性功能狀況。方法:對66例慢性肝病患者,以采用國際勃起功能指數 (IIEF-5)為評價指標。采用問卷調查的方式患者自行填寫,總結患者的得分。同時收集患者年齡和體重指數(BMI)資料。結果:66例男性患者中 IIEF-5評分最高為25分,最低為3分其中≥21分30例, 12~20分21例,8~11分7例,<7分8例。無勃起功能障礙(ED)的為45.5%(30/66) ,有ED 54.5%(36/66),其中輕度ED 31.8%(21/66),中度ED 10.6%(7/66),重度ED 12.1%(8/66)。在Child-Pugh A、B級與C級相比較中發現:(1)勃起功能指數存在顯著性差異(均p<0.01);(2)五項評價指標中,除了第一項評價指標差異無顯著性外,其余四項均存在顯著性差異(均P<0.001)。結論:慢性肝病患者存在性功能障礙,Child-Pugh C級患者性功能障礙較為嚴重,應加強對慢性肝病患者性功能障礙的治療,以提高患者的生存質量。
【關鍵詞】慢性肝病;性功能;國際勃起功能問卷表
Assessment of the sexual functions of males with chronic liver diseaseDAI Liejun1, PANG Hong1, HUANG Tiejun1, WANG Hai2. 1.Department of Infectious Diseases, 2nd Affiliated Hospital of Hubei University of Science and Technology, Xianning 437100, Hubei, China.; 2. Department of Urology, Xianning First Peoples Hospital, Xianning 437000, Hubei, China
【Abstract】Objectives: To analyze the erectile function (EF) of patients with chronic liver disease. Methods: 66 male patients with chronic liver disease were investigated with Questionnaire for International Index of Erectile Function (IIEF-5). Data of body mass index of patients also was collected. Results: Among the 66 cases, the maximum IIEF-5 score was 25 points and the minimum IIEF-5 score was 3 points. 30 cases scored greater than 21points; 21 cases scored between 20 and 12 points and 7 cases scored between 11and 8; 8 cases scored less than 7 points. 45.5% (30/66) had no erectile dysfunction (ED) whereas 54.5%% (34/59) had ED. The ration of mild ED, moderate ED and severe ED were 31.8% (21/66), 10.6% (7/66) and 12.1% (8/66) respectively. There was significant score difference between child-Pugh grade A, B and grade C. Grade A, B scored higher in item 2, 3, 4 than grade C except for item 1. Conclusion: ED exists in male patients with chronic liver disease, especially in grade C patients. Special attention should be paid to the sexual function of patients with chronic liver disease, to improve their life quality.
【Key words】Chronic liver disease; Sexual function; Questionnaire for International Index of Erectile Function (IIEF-5)
【中圖分類號】R698【文獻標志碼】A
慢性肝病(chronic liver disease,CLD)是一種以肝細胞進行性壞死導致肝纖維化和肝硬化的疾病,這一過程可以持續6個月或更長的時間。導致慢性肝病的原因主要有病毒的原因、有毒藥物、酒精性肝病、非酒精性脂肪肝病、自身免疫性肝病等。我國存在眾多慢性肝病患者。我國的慢性肝病患者主要是慢性病毒性肝炎,主要是乙肝、丙肝患者,以及由此導致的肝硬化(LC),甚至肝細胞癌(HCC)。性功能障礙是患有慢性疾病如糖尿病和高血壓等常見的情況。勃起功能障礙是關系健康的一個重要因素。國外對患慢性肝病白種人群的調查發現存在性功能障礙,并可在肝移植后改善[1,2]。日本學者研究發現慢性肝病患者的性功能障礙與慢性肝病的Child-Pugh分級相關[3]。本研究旨在調查評估我國慢性肝病患者性功能狀態。
1資料與方法
1.1一般資料
選擇2011年6月至2014年5月在本院住院的慢性肝病患者。入選條件為:(1)男性年齡在18~80歲;(2)慢性肝病診斷明確;(3)固定女性伴侶健在;(4)排除引起男性勃起功能障礙(erectile dysfunction ED)的其他因素 如心血管病、糖尿病、高脂血癥、抑郁癥、高血壓,男性外生殖器系統手術史、前列腺手術史、尿道手術史并排除真假兩性畸形患者,患者主觀不愿意參與及神志不清或昏迷患者。……