芐星青霉素治療梅毒硬下疳的效果及血清IL—27和IL—33水平影響分析

付曼妮+解翠林+石年

【摘要】目的：分析芐星青霉素治療梅毒硬下疳的效果及對血清IL-27和IL-33水平影響。方法：選擇2013年6月至2015年4月期間在我院進行過梅毒硬下疳治療的54例患者，并將其隨機分為對照組（27例）和觀察組（27例），對照組患者行常規梅毒治療，觀察組患者行正規驅梅治療（芐星青霉素）。比較兩組患者皮損愈合情況、療效、血清IL-27和IL-33水平變化情況以及不良反應，從而探討芐星青霉素對梅毒硬下疳的治療效果以及對血清IL-27和IL-33水平變化的影響。結果：治療14d后，觀察組患者皮損愈合例數明顯高于對照組皮損愈合例數（P<0.05）。治療前，兩組患者血清IL-27和IL-33濃度比較無差異（P>0.05）；治療后，觀察組血清IL-27和IL-33濃度下降幅度均明顯大于對照組（P<0.05）。觀察組總有效率77.78%明顯高于對照組總有效率29.63%（P<0.05）。治療后，兩組患者均出現輕微嘔吐、上腹不適等不良反應，且例數比較無差異（P>0.05）。結論：芐星青霉素能夠有效地縮短患者皮損愈合時間，提高治愈率，降低血清IL-27和IL-33水平，具有臨床價值。

【關鍵詞】芐星青霉素；IL-27；IL-33；梅毒硬下疳

Effect of benzathine penicillin treatment on syphilis chancre and impact on levels of serum IL-27 and IL-33FU Manni， XIE Cuilin△， SHI Nian. Department of Dermatology， Puai Branch of Huangshi Central Hospital ，Edong Healthcare Group， Huangshi 435000，Hubei，China

【Abstract】Objectives： To analyze the effect of benzathine penicillin treatment on syphilis chancre and its impact on levels of serum IL-27 and IL-33. Methods： 54 syphilitic chancre patients from June 2013 to April 2015 were selected and divided into two groups. Control group （27 cases） received conventional syphilis treatment and observation group （27 cases） received normal drive treatment （penicillin G）. Lesions healing time， the cure rate， serum IL-27 and IL-33 levels changes and adverse reactions and the therapeutic effect of syphilis hard chancre of two groups were compared so as to explore the effect of benzathine penicillin treatment and its influence on levels of serum IL-27 and IL-33. Results： After 14 days of treatment， the number of lesions in observation group was significantly higher than that of control group （P<0.05）. Before treatment， levels of serum IL-27 and IL-33 in the two groups had no difference （P>0.05）； after treatment， levels of serum IL-27 and IL-33 in the observation group were significantly higher than those in control group， with statistically significant difference （P<0.05）. The total effective rate of observation group was significantly higher than that of control group， with statistically significant difference （P<0.05）. After treatment， both groups occurred mild vomiting， abdominal discomfort and other adverse reactions， and no significant difference was found （P> 0.05）. Conclusion： Benzathine penicillin can effectively shorten the healing time of patients with skin lesions， improve the cure rate， and reduce serum IL-27 and IL-33 levels， which is worth of clinical application.

【Key words】Benzathine penicillin； IL-27； IL-33； Syphilis chancreendprint

【中圖分類號】R759.1【文獻標志碼】A

梅毒硬下疳是一種常見的生殖器傳染疾病，由蒼白螺旋體產生[1]。梅毒一般分為一期梅毒、二期梅毒和三期梅毒。其中一期梅毒包括梅毒硬下疳，發生于感染后10～30d內，表現為無痛性紅色硬結；二期梅毒是在一期梅毒未經治療或者治療不當的情況下發展形成，70%左右的二期梅毒患者表現為皮疹；三期梅毒發生于感染后2年及以上，嚴重危害患者的健康[2]。目前對該疾病的治療藥物主要有芐星青霉素、阿奇霉素等[3]。本次研究選用芐星青霉素對梅毒硬下疳患者進行治療，尋求更有效的治療方案。現報道如下。

1一般資料與方法

1.1一般資料