乳酸桿菌活菌制劑治療陰道炎效果和安全性分析

時建榮 黃慶義 楊瑞

【摘要】目的：探討乳酸桿菌活菌制劑治療陰道炎的有效性及安全性。方法：選取344例陰道炎患者隨機均分為觀察組和對照組，觀察組采用甲硝唑聯合乳酸桿菌活菌制劑治療，對照組采用甲硝唑治療，比較兩組臨床療效、不良反應發生及隨訪期間復發情況。結果：觀察組細菌性陰道病、念珠菌性陰道炎及滴蟲性陰道炎痊愈率和有效率均明顯高于對照組，治療后3、6、9個月復發率低于對照組，差異具有統計學意義（P<0.05）；對照組不良反應發生率為4.7%（4/86），觀察組僅出現3例輕度不良反應，發生率為3.5%，且治療前后血尿常規及肝腎功能檢查指標均無顯著性變化（P>0.05），兩組不良反應發生率差異無統計學意義（P>0.05）。結論：乳酸桿菌活菌制劑治療陰道炎患者安全有效，可在臨床上推廣。

【關鍵詞】乳酸桿菌活菌制劑；陰道炎；有效性；安全性

Efficacy and safety analysis of live lactobacillus preparation in patients with vaginitisSHI Jianrong1， HUANG Qingyi2， YANG Rui2. 1.Department of Gynecology and Obstetrics， Jiyuan Hospital of Chinese Traditional Medicine， Jiyuan 454650， Henan， China； 2. Department of Gynecology and Obstetrics，Nanyang Central Hospital， Nanyang 473002， Henan， China

【Abstract】Objectives： To explore the efficacy and safety of live lactobacillus preparation in patients with vaginitis. Methods： 172 patients with vaginitis were randomly divided into observation group and control group. Observation group received the treatment of metronidazole combined with live lactobacillus preparation and control group was treated with metronidazole. The clinical efficacy， adverse reactions and recurrence of two groups were compared. Results： The recovery rate and efficiency of bacterial vaginitis， candida vaginitis and trichomonas vaginitis of observation group were significantly higher than these in control group. The recurrence rate of the 3， 6 and 9 months after treatment in observation group were lower than these in control group， with statistically significant difference （P<0.05）. The incidence of adverse reactions in the control group was 4.7% （4/86）. There were only 3 cases of mild adverse reactions in the observation group， an incidence rate of 3.5%. There were no significant changes in the hematuria routine and liver and kidney function test before and after the treatment （P>0.05）， without significant difference in the incidence of adverse reactions between two groups （P>0.05）. Conclusion： The treatment of live lactobacillus preparation in patients with vaginitis is safe and effective， which can be applied in clinical practice.

【Key words】Live lactobacillus preparation； Vaginitis： Efficacy； Safety

【中圖分類號】R711.31【文獻標志碼】A

陰道炎屬于一種常見的婦科疾病，是病原微生物感染引起的多種陰道黏膜疾病的總稱，常見病原體包括細菌、念球菌、陰道毛滴蟲及支原體等。其發生機制主要為陰道菌群失調，尤其是可產生H2O2的乳酸桿菌急劇減少或消失，厭氧菌群異常增加[1]。臨床研究表明，多種病原微生物均可引起陰道炎，治療陰道炎的關鍵是重建陰道微生態系統，改善陰道防御能力，提高臨床療效，降低復發率[2]。目前陰道炎的治療效果不甚理想，患者依從性差，復發率高。臨床上常采用抗生素或雌激素治療陰道炎，其中抗生素在殺滅致病菌的同時也破壞陰道正常菌群，進而導致陰道微生態失調，使患者病情反復，遷延難愈，在很大程度上影響患者的生活質量。本研……