鐵補(bǔ)充劑聯(lián)合食物療法治療兒童缺鐵性貧血的效果

王志國(guó)

【摘要】 目的 探討鐵補(bǔ)充劑聯(lián)合食物療法治療兒童缺鐵性貧血的臨床療效。方法 85例缺鐵性貧血患兒為研究對(duì)象， 以隨機(jī)數(shù)字表法分為觀察組（43例）與對(duì)照組（42例）。對(duì)照組患兒?jiǎn)斡描F補(bǔ)充劑治療， 觀察組患兒采用鐵補(bǔ)充劑聯(lián)合食物療法治療。對(duì)兩組患兒治療后臨床療效及營(yíng)養(yǎng)指標(biāo)變化進(jìn)行觀察。結(jié)果 觀察組治療總有效率為93.02%， 高于對(duì)照組的73.81%， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療前， 兩組患兒血紅蛋白（Hb）、紅細(xì)胞（RBC）、平均紅細(xì)胞體積（MCV）、平均紅細(xì)胞血紅蛋白濃度（MCHC）比較差異均無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）；治療后， 兩組Hb、RBC、MCV、MCHC均優(yōu)于本組治療前， 且觀察組均優(yōu)于對(duì)照組， 差異均具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療前， 兩組患兒轉(zhuǎn)鐵蛋白飽和度（TSAT）、血清鐵（SI）比較差異均無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）；治療后， 兩組TSAT、SI均優(yōu)于本組治療前， 且觀察組均優(yōu)于對(duì)照組， 差異均具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 鐵補(bǔ)充劑聯(lián)合食物療法可有效治療兒童缺鐵性貧血， 其血液指標(biāo)及鐵代謝指標(biāo)均較單純鐵補(bǔ)充劑水平優(yōu)良， 值得臨床推廣。

【關(guān)鍵詞】 食物療法；鐵補(bǔ)充劑；缺鐵性貧血

DOI：10.14163/j.cnki.11-5547/r.2018.01.049

【Abstract】 Objective To discuss the clinical efficacy of iron supplement combined with food therapy in the treatment of iron deficiency anemia in children. Methods A total of 85 children with iron deficiency anemia were divided by random number table method into observation group （43 cases） and control group （42 cases）. The control group was treated with simple iron supplement， and the observation group was treated with iron supplement combined with food therapy. Observation were made on clinical efficacy and changes of nutrition index after treatment between two groups. Results The observation group had higher total treatment effective rate as 93.02% than 73.81% in the control group， and the difference was statistically significant （P<0.05）. Before treatment， both groups had no statistically significant difference in hemoglobin （Hb）， red blood cell （RBC）， mean corpuscular volume （MCV）， mean red blood cell hemoglobin concentration （MCHC） （P>0.05）. After treatment， both groups had better Hb， RBC， MCV and MCHC than before treatment， and the observation group was better than the control group. Their difference was statistically significant （P<0.05）. Before treatment， both groups had no statistically significant difference in transferrin saturation （TSAT） and serum iron （SI） （P>0.05）. After treatment， both groups had better TSAT and SI than before treatment， and the observation group was better than the control group. Their difference was statistically significant （P<0.05）. Conclusion Combination of iron supplement and food therapy can effectively treat children with iron deficiency anemia， and its blood and iron metabolism indicators are superior to those of single iron supplement. It is worthy of clinical promotion.

【Key words】 Food therapy； Iron supplement； Iron deficiency anemia

兒童缺鐵性貧血是較為常見(jiàn)的小兒時(shí)期綜合征， 主要表現(xiàn)為單位體積周?chē)旱腍b、RBC及紅細(xì)胞壓積低于正常值[1]。兒童缺鐵性貧血不僅會(huì)對(duì)生長(zhǎng)發(fā)育造成嚴(yán)重影響， 也會(huì)降低機(jī)體免疫功能， 極易誘發(fā)感染性疾病。同時(shí)， 兒童缺鐵性貧血大多起病緩慢， 未及時(shí)引起家長(zhǎng)注意， 至發(fā)現(xiàn)時(shí)多數(shù)較為嚴(yán)重， 對(duì)身心發(fā)展均造成一定危害。有數(shù)據(jù)顯示[2]， 中國(guó)2005年的兒童缺鐵性貧血發(fā)生率為12%～20%， 近年各國(guó)兒童貧血發(fā)生率依然居高不下。臨床治療兒童缺鐵性貧血主要采用鐵補(bǔ)充劑治療， 但是有學(xué)者提出采用飲食療法， 可提高患兒治療依從性， 也利于遠(yuǎn)期預(yù)后。本研究為探討兒童缺鐵性貧血最佳治療方案， 采用鐵補(bǔ)充劑聯(lián)合食物療法治療， 現(xiàn)報(bào)告如下。endprint

1 資料與方法

1. 1 一般資料 選擇本院2015年3月～2016年4月收治的85例缺鐵性貧血患兒為研究對(duì)象， 以隨機(jī)數(shù)字表法分為觀察組（43例）與對(duì)照組（42例）。……