鹽酸米諾環素聯合布洛芬對慢性牙周炎的療效觀察

趙雪奎

【摘要】 目的 探討鹽酸米諾環素聯合布洛芬對慢性牙周炎的臨床療效。方法 120例慢性牙周炎患者， 隨機分成觀察組和對照組， 每組60例。兩組患者均予以超聲潔刮治療， 對照組使用鹽酸米諾環素治療， 觀察組使用鹽酸米諾環素聯合布洛芬治療， 比較兩組患者治療效果以及治療前后的菌斑指數、菌落數量、齦溝出血指數。結果 治療后， 兩組患者的菌斑指數、菌落數量、齦溝出血指數均明顯低于治療前， 觀察組患者的菌斑指數、菌落數量、齦溝出血指數明顯低于對照組， 差異具有統計學意義（P<0.05）。觀察組患者的治療總有效率為98.3%， 顯著高于對照組的85.0%， 差異具有統計學意義（P<0.05）。

結論 鹽酸米諾環素聯合布洛芬對慢性牙周炎的療效明顯， 值得推廣應用。

【關鍵詞】 鹽酸米諾環素；布洛芬；慢性牙周炎；臨床療效

DOI：10.14163/j.cnki.11-5547/r.2018.02.048

Observation of the efficacy of minocycline hydrochloride and ibuprofen in the treatment of chronic periodontitis ZHAO Xue-kui. Department of Stomatology， Shandong Tancheng First Peoples Hospital， Linyi 276199， China

【Abstract】 Objective To discuss the clinical efficacy of minocycline hydrochloride and ibuprofen in the treatment of chronic periodontitis. Methods A total of 120 chronic periodontitis patients were randomly divided into observation group and control group， with 60 cases in each group. Both groups received ultrasonic curettage therapy， and the control group received minocycline hydrochloride for treatment. The observation group received minocycline hydrochloride and ibuprofen for treatment. Comparison were made on treatment effect， plaque index， colony number， gingival bleeding index before and after treatment between two groups. Results After treatment， both groups had obviously lower plaque index， colony number， gingival bleeding index than before treatment， and the observation group had obviously lower plaque index， colony number， gingival bleeding index than the control group. Their difference was statistically significant （P<0.05）. The observation group had obviously higher total treatment effective rate as 98.3% than 85.0% in the control group， and the difference was statistically significant （P<0.05）. Conclusion Combination of minocycline hydrochloride and ibuprofen provides remarkable efficacy for chronic periodontitis， and is worthy of promotion and application.

【Key words】 Minocycline hydrochloride； Ibuprofen； Chronic periodontitis； Clinical efficacy

牙周炎多是由細菌感染引發的口腔疾病， 慢性牙周炎占近95%， 炎癥由牙齦不斷擴散至牙周膜、牙槽骨、牙骨質發展而成， 進行形成牙周袋、牙周溢膿、牙齒松動等， 對患者的生活造成影響。慢性牙周炎的治療原則是首先需將菌斑、牙石等誘發因素徹底清除， 進而改善牙齦炎癥， 緩解牙周袋癥狀， 并爭取促進牙周組織再生。有研究指出[1]牙周炎可能成為冠心病、糖尿病等系統性疾病危險因素， 全身系統性的疾病同牙周炎也有關聯。因此及早改善癥狀， 促進牙周組織功能康復在口腔治療中有重要臨床意義。抗菌藥物治療是牙周炎治療的主要方案， 鹽酸米諾環素是廣譜抗生素， 布洛芬具有抗炎鎮痛之效， 本文探討兩者聯合應用治療慢性牙周炎的臨床療效， 現報告如下。……