周偉 傅玉瓊 范秀云 張明偉


【摘要】 目的:研究顯微外科手術在顱內動脈瘤中的應用效果及對患者應激程度的影響。方法:選取2017年4月-2018年1月筆者所在醫院收治的82例顱內動脈瘤患者為研究對象,將其隨機分為兩組,每組41例。對照組進行血管內介入治療,觀察組則進行顯微外科夾閉手術治療。比較兩組患者術后不同時間的GOS評分、手術前后的血清應激激素。結果:觀察組術后1周及4周GOS評分優于對照組(P<0.05),由術前至術后1、3 d兩組內血清應激激素均先升后降,但兩組見差異無統計學意義(P>0.05)。結論:顯微外科手術在顱內動脈瘤中的應用效果較好,且對患者的不良應激尚可,故在顱內動脈瘤患者中的應用價值較高。
【關鍵詞】 顯微外科手術; 顱內動脈瘤; 應用效果; 應激程度
doi:10.14033/j.cnki.cfmr.2019.03.014 文獻標識碼 B 文章編號 1674-6805(2019)03-00-02
Study on the Application Effect of Microscopic Surgery in the Patients with Intracranial Aneurysm and Influence for the Stress Degree/ZHOU Wei,FU Yuqiong,FAN Xiuyun,et al.//Chinese and Foreign Medical Research,2019,17(3):-35
【Abstract】 Objective:To study the application effect of microscopic surgery in the patients with intracranial aneurysm and influence for the stress degree.Method:A total of 82 patients with intracranial aneurysm in hospital from April 2017 to January 2018 were chosen as the research object,and they were randomly into two groups,with 41 cases in each group.The control group were treated with endovascular interventional treatment,the observation group were treated with microsurgical clipping.Then the GOS score at different time after the operation,serum stress hormones before and after the operation of two groups were compared.Result:The GOS score of observation group at first and forth week after the operation were better than those of control group(P<0.05),the serum stress hormones of two groups before the operation and at first and third day after the operation increased first and decreased afterward,while the differences of two groups were not statistically significant(P>0.05).Conclusion:The application effect of microscopic surgery in the patients with intracranial aneurysm is better,and its bad influence for the patients is still available,so its application value in the patients with intracranial aneurysm is higher.
【Key words】 Microscopic surgery; Intracranial aneurysm; Application effect; Stress degree
First-authors address:Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University,Luzhou 646000,China
顱內動脈瘤是發生于顱內動脈的一類病變,也是導致蛛網膜下腔出血的重要原因,且發病的年齡廣泛,臨床危害明顯,因此臨床對于本病的重視程度較高,相關的治療研究多見。臨床中近年來關于顯微外科手術與血管內介入治療的研究多見,但兩類治療方式的效果比較研究爭議較大[1-2],尤其是對于臨床效果及機體應激反應方面的研究差異較大。因此本研究就顯微外科手術在顱內動脈瘤中的應用效果及對患者應激程度的影響進行研究,并與血管內介入治療的患者進行比較,結果總結如下。
1 資料與方法
1.1 一般資料
選取2017年4月-2018年1月筆者所在醫院收治的82例顱內動脈瘤患者為研究對象,將其隨機分為兩組,每組41例。納入標準:年齡20~75歲;符合顱內動脈瘤手術指征者;對研究知情同意者。排除標準:合并其他心肺肝腎等疾病者;合并內分泌性疾病者;合并其他腦部感染或疾病者;精神病史者。對照組中包括男21例,女20例,年齡22~73歲,平均(56.9±5.6)歲,其中前循環18例,后循環23例;Hunt-Hess分級:Ⅰ級者20例,Ⅱ級者16例,Ⅲ級者5例。觀察組中包括男22例,女19例,年齡23~74歲,平均(57.1±5.8)歲,其中前循環17例,后循環24例;Hunt-Hess分級:Ⅰ級者20例,Ⅱ級者15例,Ⅲ級者6例。兩組性別、年齡、部位及Hunt-Hess分級等方面比較,差異無統計學意義(P>0.05),具有可比性。本研究經醫院倫理委員會批準。