肖雁 鄭小泳 梁麗卿 李娟花 黃鐘展

【摘要】 目的:探討氯胺酮為麻醉劑的MECT效果。方法:將2017年4月-2019年4月于筆者所在醫(yī)院進(jìn)行MECT治療的102例患者作為研究對(duì)象,按照隨機(jī)數(shù)字法分為兩組,對(duì)照組52例,觀察組50例。對(duì)照組行丙泊酚麻醉,觀察組行氯胺酮麻醉。對(duì)比兩組臨床指標(biāo)及陽(yáng)性與陰性癥狀量表(PANSS)評(píng)分,并記錄治療過(guò)程中不良反應(yīng)情況。結(jié)果:治療后,觀察組抽搐能量指數(shù)為(15 102±3 305),低于對(duì)照組的(20 001±3 518),
差異有統(tǒng)計(jì)學(xué)意義(P<0.05);觀察組治療后陽(yáng)性及陰性因子評(píng)分分別為(12.25±3.12)、(16.74±4.25)分,均低于對(duì)照組的(18.71±3.87)、(24.89±7.79)分,差異均有統(tǒng)計(jì)學(xué)意義(P<0.05);觀察組不良反應(yīng)發(fā)生率為10.00%,低于對(duì)照組的59.62%,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論:在進(jìn)行MECT治療過(guò)程中,氯胺酮與丙泊酚具有相近的麻醉效果,但前者能顯著改善PANSS評(píng)分,且不良反應(yīng)發(fā)生率低,安全性更高,值得在臨床中推廣使用。
【關(guān)鍵詞】 氯胺酮 麻醉劑 MECT
doi:10.14033/j.cnki.cfmr.2020.08.016??文獻(xiàn)標(biāo)識(shí)碼 B??文章編號(hào) 1674-6805(2020)08-00-03
MECT Effect of Ketamine as Anesthetics/XIAO Yan, ZHENG Xiaoyong, LIANG Liqing, LI Juanhua, HUANG Zhongzhan. //Chinese and Foreign Medical Research, 2020, 18(8): -41
[Abstract] Objective: To study the MECT effect of Ketamine as anesthetics. Method: A total of 102 patients who were treated with MECT in our hospital from April 2017 to April 2019 were selected as the study objects and divided into two groups according to the random number method, 52 cases in the control group and 50 cases in the observation group. The control group was given Propofol anesthesia and the observation group was given Ketamine anesthesia. Clinical indicators and positive and negative symptom scale (PANSS) scores of the two groups were compared, and the adverse reactions were recorded. Result: After treatment, the twitch energy index of the observation group was (15 102±3 305), which was lower than (20 001±3 518) of the control group, and the difference was statistically significant (P<0.05). After treatment, the scores of positive and negative factors of the observation group were (12.25±3.12), (16.74±4.25) points, which were lower than (18.71±3.87), (24.89±7.79) points of the control group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions of the observation group was 10.00%, which was lower than 59.62% of the control group, and the difference was statistically significant (P<0.05). Conclusion: Ketamine and Propofol have similar anesthetic effect in MECT treatment, but the former can improve the PANSS score greatly, and the incidence of adverse reactions is lower and the safety is higher, which is worthy of clinical application.
[Key words] Ketamine Anesthetics MECT
First-authors address: Jiangmen Third Peoples Hospital, Jiangmen 529000, China
精神病為臨床中常見(jiàn)疾病,主要采用抗精神疾病藥物治療,但對(duì)于部分患者并無(wú)明顯臨床效果,且易發(fā)展為難治性精神病,對(duì)預(yù)后產(chǎn)生嚴(yán)重影響[1]。隨著近年來(lái)醫(yī)療技術(shù)的不斷發(fā)展,針對(duì)精神病的臨床特點(diǎn),在采用藥物治療的同時(shí)多聯(lián)合無(wú)抽搐電休克治療(MECT),可有效控制精神癥狀,提升效果[2]。在進(jìn)行MECT過(guò)程中,常使用丙泊酚等作為麻醉藥物,雖能取得較好的麻醉效果,但常伴有不良反應(yīng),對(duì)患者預(yù)后造成影響[3]。研究顯示,使用氯胺酮作為MECT麻醉劑,可降低不良反應(yīng)發(fā)生率,使麻醉安全性提升[4]。為觀察以氯胺酮為麻醉劑的MECT的臨床效果,特選取2017年4月-2019年4月于筆者所在醫(yī)院進(jìn)行MECT治療的102例患者作為研究對(duì)象行對(duì)比分析,將結(jié)果報(bào)道如下。
1 資料與方法
1.1 一般資料
將2017年4月-2019年4月于筆者所在醫(yī)院進(jìn)行MECT治療的102例患者作為研究對(duì)象。納入標(biāo)準(zhǔn):(1)符合精神疾病相關(guān)診斷標(biāo)準(zhǔn),確診為精神病;(2)麻醉ASA分級(jí)為Ⅰ級(jí)或Ⅱ級(jí)。排除標(biāo)準(zhǔn):(1)嚴(yán)重心腦血管疾病;(2)肝腎功能障礙;(3)對(duì)本研究麻醉劑過(guò)敏。……