老年慢性阻塞性肺氣腫患者49例療效觀察

[摘要] 目的 觀察抗生素聯合糖皮質激素用于老年慢性阻塞性肺氣腫的臨床療效。 方法 對筆者所在醫院收治的49例老年慢性阻塞性肺氣腫患者隨機分成兩組，對照組25例與觀察組24例，對照組采用常規治療，觀察組采用糖皮質激素配合常規治療的治療方法，分析比較對照組與觀察組的療效與不良反應。 結果 經過常規治療，對照組總有效率為64.0%；觀察組總有效率為91.7%，兩組比較差異有統計學意義（P<0.05）；治療過程中對照組2例出現不良反應，觀察組3例出現不良反應；兩組不良反應的發生情況比較差異無統計學意義（P>0.05）。 結論 抗生素聯合糖皮質激素用于老年慢性阻塞性肺氣腫治療，與常規治療相比療效顯著，值得在臨床治療中予以推廣。

[關鍵詞] 抗生素；糖皮質激素；老年慢性阻塞性肺氣腫；療效

[中圖分類號] R563 [文獻標識碼] B [文章編號] 2095-0616（2012）21-186-02

Efficacy of 49 elderly patients with chronic obstructive pulmonary emphysema patients

SHI Bo CUI Huifang TANG Bujie LIU Nuanlin LI Yuanhui BAO Xiaoli

ICU， Liaobu Hospital of Dongguan City， Dongguan 523400， China

[Abstract] Objective To observe the clinical efficacy of antibiotics combined with glucocorticoids for elderly patients with chronic obstructive pulmonary emphysema. Methods 49 elderly patients with chronic obstructive pulmonary emphysema patients were randomly divided into two groups. The control group with 25 patients took the conventional therapy， the observation group with 24 patients took the antibiotics combined with glucocorticoids therapy .Compared the efficacy and adverse effects between the two groups. Results After conventional treatment， the total effective rate of the control group was 64.0%， the total effective rate of the observation group was 91.7%. The difference of the total efficiency of treatment in both groups was statistically significant（P<0.05）. In treatment process， 2 cases of the control group had adverse reactions， and 3 cases of the observation group had adverse reactions .The incidence of adverse reactions between the two groups was no difference（P>0.05）. Conclusion The treatment of antibiotics combined with glucocorticoids for elderly patients with chronic obstructive pulmonary emphysema is better than the conventional therapy. It is worthy to be promoted in the clinical treatment.

[Key words] Antibiotics； Glucocorticoids； Elderly patients with chronic obstructive pulmonary emphysema； Efficacy

慢性阻塞性肺氣腫的發病機理通常認為是人體長期受吸煙、有害氣體、空氣污染、粉塵、感染等因素刺激而引起終末細支氣管遠端受損[1]，是一種發病緩慢而且病程較長的常見疾病。老年人因體質弱于青壯年，易受空氣污染、寒冷等影響而患有慢性阻塞性肺氣腫，嚴重損害了老年人的身體健康，影響了他們的生活質量[2]。由于老年患者往往不愿進行手術治療，通常采用保守治療方法，現結合筆者所在醫院2009年2月～2011年2月收治的49例老年慢性阻塞性肺氣腫患者治療資料，報道抗生素聯合糖皮質激素治療該病的實際效果，具體如下。……