活血降糖飲對2型糖尿病大血管病變的影響

[摘要] 目的 研究活血降糖飲對2型糖尿病患者頸動脈內-中膜厚度、粥樣硬化斑塊面積、粥樣硬化斑塊檢出率的影響，尋求糖尿病大血管并發癥的防治方法。 方法 共收集氣陰兩虛血瘀型2型糖尿病患者180例，隨機分為對照組、治療組各90例。對照組采用降壓、降脂、降糖及抗血小板聚集等綜合治療。治療組在此基礎上，加服益氣養陰活血中藥湯劑活血降糖飲。療程為6個月。入組及療程結束時行頸動脈彩超檢查，分析治療前后頸動脈內-中膜厚度，粥樣硬化斑塊面積、粥樣硬化斑塊檢出率的變化情況。 結果 兩組患者治療后，頸動脈內-中膜厚度、粥樣硬化斑塊檢出率均有改善，差異有統計學意義（P<0.05）。與對照組相比，治療組改善更明顯，差異有統計學意義（P<0.05）。 結論 在綜合治療基礎上加用活血降糖飲治療，患者頸動脈內-中膜厚度、粥樣硬化斑塊面積明顯下降，說明益氣養陰活血法能延緩動脈粥樣硬化的發生發展，可有效預防糖尿病大血管并發癥。

[關鍵詞] 活血降糖飲；2型糖尿病；頸動脈內-中膜厚度

[中圖分類號] R259 [文獻標識碼] A [文章編號] 2095-0616（2012）21-16-03

Effect of Huoxue Jiangtang Yin on type 2 diabetes complications of macrovascular

LI Zengying LI Huilin QU Xin LI Jinhua

Shenzhen Chinese Traditional Medical Hospital， Shenzhen 518033，China

[Abstract] Objective To investigate the effect of Huoxue Jiangtang Yin on carotid arterial intima-media thickness， plaque area and atherosclerotic plaque rate of type 2 diabetic patients， and seek the prevention of diabetic macrovascular complications. Methods 180 type 2 diabetes mellitus patients of Qi and Yin deficiency and blood stasis were collected， and randomly divided into control group and treatment group with 90 patients in each group. The patients in control group were treated with comprehensive therapy including hypotensors， lipid regulating drugs， hypoglycemic agents and platelet aggregation inhibitors， while in treatment group， the comprehensive therapy was used and Huoxue Jiangtang Yin was added. All patients were treated for 6 months. At the beginning and the end of the treatment， carotid arterial intima-media thickness， plaque area and atherosclerotic plaque rate were examined by carotid artery color Doppler ultrasound to analyze the changes on the above indexes. Results Carotid arterial intima-media thickness and atherosclerotic plaque rate were significantly ameliorated after 6-month treatment compared to that before the treatment （P<0.05）. In addition， compared with the control group， the treatment group improved more obviously （P<0.05）. Conclusion When the comprehensive therapy was added with Huoxue Jiangtang Yin， the carotid arterial intima-media thickness and atherosclerotic plaque rate of patients were significantly ameliorated， indicating that the Yiqi， Yangyin and Huoxue method is effective in delaying the development of atherosclerosis and preventing diabetic macrovascular complications.

[Key words] Huoxue Jiangtang Yin； Type 2 diabetes； Carotid arterial intima-media thickness

近年來，隨著2型糖尿病患病率的增加，糖尿病大血管并發癥的發生率亦逐年升高。而大血管并發癥是糖尿病患者致死致殘的主要原因之一[1]。糖尿病大血管病變包括心、腦和周圍大血管病變，主要是以動脈粥樣硬化為病理基礎，累及主動脈、冠狀動脈、腦動脈、腎動脈及下肢動脈等，與單純的動脈粥樣硬化相比，其病變范圍大、程度重、發生早[2-3]。……