奧美拉唑與西咪替丁防治胃潰瘍復發的臨床觀察

[摘要] 目的 探討預防和治療胃潰瘍復發患者使用奧米拉唑和西咪替丁的功效。 方法 選取2010年1～12月使用胃鏡檢查確診為胃潰瘍活動期的患者共250例，分成4組，A組使用奧美拉唑治療胃潰瘍，B組使用西咪替丁治療胃潰瘍，C組使用奧美拉唑預防胃潰瘍，D組使用西咪替丁預防胃潰瘍，將這兩組治療和兩組預防的效果進行對比。 結果 A組和B組治療胃潰瘍停止用藥1年后，A組復發率低于B組。C組和D組預防治療1年，C組患者胃潰瘍復發的概率要比D組低。 結論 奧美拉唑防治胃潰瘍的效果要比西咪替丁更有效和長久，使用奧美拉唑進行潰瘍治療是值得被推廣使用的。

[關鍵詞] 奧美拉唑；西咪替丁；防治；胃潰瘍

[中圖分類號] R573.1 [文獻標識碼] B [文章編號] 2095-0616（2012）21-78-02

Clinical observation of omeprazole and cimetidine for the prevention and control of gastric ulcer recurrence

LI Bangquan

Department of Digestive， the Third People's Hospital of Jiujiang City， Jiujiang 332000，China

[Abstract] Objective To explore the prevention and treatment of omeprazole and cimetidine for the prevention and control of gastric ulcer recurrence. Methods A total of 250 cases of gastric ulcer activity in our hospital diagnosed by endoscopy from January 2010 to December 2010 were divided into four groups， patients of group A used omeprazole for gastric ulcer， patients of group B used cimetidine treatment of gastric ulcer， patients of group C used omeprazole to prevent of gastric ulcers， patients of group D used cimetidine to prevent of gastric ulcers. Compared with the treatment and preventive effect of these two groups. Results The risk of recurrent group A treatment of gastric ulcer were lower than group B after stopped the medication for 1 year.The recurrence probability of group C prevention and treatment was lower than the group D after 1 year. Conclusion This article explore research derived effective than cimetidine is more effective and long-term of omeprazole prevention of gastric ulcer.Use of omeprazole in ulcer therapy is worthy to be popularized.

[Key words] Omeprazole；Cimetidine；Prevention and treatment；Gastric ulcer

奧美拉唑又稱洛賽克，是可以有效抑制胃酸分泌的一種質子泵抑制劑。奧美拉唑一般用于以下4種病況：（1）患者患有消化性潰瘍出血、吻合口潰瘍出血。（2）患者在應激狀態時并發的急性胃黏膜損害，以及非甾體類抗炎藥所引發的急性胃黏膜損害。（3）可以預防嚴重疾病胃手術后再出血等，例如腦出血以及嚴重創傷。（4）患者在全身麻醉或者是大手術以后和昏迷患者防止胃酸反流合并吸入性肺炎[1-2]。西咪替丁也是一種抑制胃酸分泌的藥物，能夠顯著抑制基礎以及夜間胃酸分泌，還能夠抑制由分肽胃泌素、胰島素、組胺以及食物等的刺激引發的胃酸分泌，并且使酸度下降，對于因為化學刺激引發的腐蝕性胃炎有預防與保護的作用，對于應激性胃潰瘍以及上消化道出血也有顯著效果。……