姜玉華+施軍平
[摘要] 目的 分析生活方式干預對多烯磷脂酰膽堿治療非酒精性脂肪肝臨床療效的影響。方法 選擇146例非酒精性脂肪肝患者,分別給予多烯磷脂酰膽堿治療及生活方式干預輔助多烯磷脂酰膽堿治療,比較治療前后肝功能及血脂指標、肝臟彩超影像圖、BMI及平均腰圍、生活質量等。結果 觀察組治療后ALT、AST、TBIL、TG、TC、LDL-C、肝腫大、BMI、平均腰圍值均明顯低于對照組;HDL-C、軀體功能、心理功能、社會功能、總體生活質量明顯高于對照組。結論 生活方式干預輔助多烯磷脂酰膽堿治療可以有效降低患者的體重,改善患者的肝功能及血脂情況,優化肝臟超聲圖像,提高其生活質量。
[關鍵詞] 非酒精性脂肪肝;多烯磷脂酰膽堿;生活方式干預;肝功能;血脂
[中圖分類號] R657.3 [文獻標識碼] B [文章編號] 1673-9701(2014)02-0103-04
Clinical curative effect of lifestyle intervention on polyene phosphatidyl choline treatment nonalcoholic fatty liver disease
JIANG Yuhua1 SHI Junping2
1.Department of Digestion Liver Disease, the Peoples Hospital of Yizhou, Ningbo 315040, China; 2.Department of Severe Liver Disease,Hangzhou No.6 Hospital,Hangzhou 310014, China
[Abstract] Objective To analyze clinical curative effect of lifestyle intervention on polyene phosphatidyl choline treatment nonalcoholic fatty liver disease. Methods A total of 146 patients with nonalcoholic fatty liver disease were divided into observation group and control group, control group was given polyene phosphatidyl choline treatment, the observation group was given lifestyle intervention auxiliary polyene phosphatidyl choline treatment, liver function, blood fat, liver exceeds the average image change, BMI, waistline, the quality of life scores were compared. Results After treatment Observation group ALT, AST, TBIL, TG, TCL, LDL-C, liver enlargement, BMI, average waistline value were significantly lower than control group; HDL-C, Physical function, psychological function, social function, quality of life were significantly higher than the control group. Conclusion Lifestyle intervention auxiliary polyene phosphatidyl choline treatment can effectively reduce the weight, improve the patient's liver function and blood lipid, optimization of liver ultrasound image, improve the quality of life.
[Key words] Nonalcoholic fatty liver disease; Polyene phosphatidyl choline; Lifestyle intervention; Liver function; Blood fat
非酒精性脂肪肝是臨床多見疾病,多與肥胖、藥物、糖尿病等密切相關,其中肥胖性脂肪肝是最為常見的一種,與不良飲食、運動習慣等直接關聯。非酒精性脂肪肝近年來在我國的發病率穩步上升,而大多數患者認為其主要由于肥胖造成,對人體無重大影響,因此在精神上未予重視,也未接受任何治療,這也是部分非酒精性脂肪肝患者逐步進展到肝硬化、肝癌等的直接原因[1,2]。因此,非酒精性脂肪肝發病后,應進行積極主動的治療,包括藥物治療及生活方式的改變,只有當兩者有效結合時才能將臨床治療效果最大化,切實保護肝細胞功能,維護患者的生活質量[3]。
本文選擇73例非酒精性脂肪肝患者,采用生活方式干預輔助多烯磷脂酰膽堿治療,同期選擇73例患者作對照,采用多烯磷脂酰膽堿治療,對比研究生活方式干預輔助多烯磷脂酰膽堿治療非酒精性脂肪肝的臨床效果,現報道如下。……