脾胃虛寒型胃潰瘍臨床研究

[摘要] 目的 探討黃芪建中湯治療脾胃虛寒型胃潰瘍的有效性與安全性。方法 采用回顧性研究的方法分析該院2013年3月—2015年3月收治的脾胃虛寒型胃潰瘍患者98例，隨機分為觀察組與對照組，各組均為49例，對照組采用奧美拉唑等西藥治療，觀察組采用黃芪建中湯加減治療，分別治療2周，治療前及6個月后進行和尿素14C呼氣試驗和胃鏡檢查，比較幽門螺旋桿菌（Hp）清除率、兩組患者治療前后潰瘍面積大小、治療總有效率及不良反應出現的情況。結果 內鏡結果顯示，胃潰瘍患者經西醫治療后，潰瘍面積減小；經中藥治療后，潰瘍創面愈合，中醫治療效果較西醫好；觀察組和對照組的Hp清除率分別為83.67%、89.80%，差異無統計學意義（P>0.05）；觀察組臨床治療總有效率是93.88%，明顯高于對照組的73.47%（P<0.05）；兩組患者治療過程中都沒有出現明顯不良反應，差異無統計學意義（P>0.05）；對照組患者隨訪期間復發7例，占比14.29%，觀察組患者隨訪期間無復發，兩組比較差異有統計學意義（P<0.05）。 結論 中醫治療脾胃虛寒型胃潰瘍臨床效果較好，不良反應及疾病復發率低，值得使用與推廣。

[關鍵詞] 中醫；脾胃虛寒型；胃潰瘍；有效性

[中圖分類號] R5 [文獻標識碼] A [文章編號] 1674-0742（2016）12（b）-0001-03

Seleen and Stomach Type Cold Stomach Ulcer Clinical Studies

ZHU Dao-bin

Sanming City， Center for Disease Control and Prevention， Sanming， Fujian Province， 365000 China

[Abstract] Objective To explore the astragalus chienchung soup treating spleen and stomach type cold efficacy and safety of the gastric ulcer. Methods Using retrospective study method of analysis in March 2013 to March 2015 taste cold type 98 cases of gastric ulcer patients， divided into observation group and control group， each group of 49 cases， control group， using western medicine treatment of omeprazole group treated with astragalus membranaceus chienchung tonga subtraction， treatment 2 weeks， respectively， before treatment and after 6 months and 14 c urea breath test and gastroscopy， comparison of helicobacter pylori （Hp） clearance， the two groups before and after treatment in patients with ulcer area size， the total effective rate and adverse reactions occur. Results According to the results of endoscopic gastric ulcer patients after treatment with western medicine， ulcer area decreased； After treatment with traditional Chinese medicine （TCM）， ulcer wound healing， Chinese medicine treatment effect is good. Hp clearance rate of observation group and control group were 83.67%， 89.80%， the difference was statistics significant（P > 0.05）； Clinical observation group total effective rate was 93.88%， significantly higher than the 73.47% in the control group，the difference was statistics significant（P < 0.05）； In the process of the two groups of patients have no obvious adverse reaction， the difference was statistics significant（P > 0.05）； Control group patients with recurrence during the follow-up period 7 cases， accounted for 14.29%， the observation group of patients without recurrence during the follow-up period， two groups the difference was statistics significant（P < 0.05）. Conclusion TCM treatment of spleen and stomach cold stomach ulcer clinical effect is good， adverse reactions and disease recurrence rate is low， is worth using and promotion.

[Key words] Traditional Chinese medicine； Spleen and stomach type cold； Gastric ulcer； Effectiveness

胃潰瘍是一種常見的消化道潰瘍疾病，中醫學認為該病屬于胃脘痛類疾病，主要病機為邪氣入侵、情志不調導致的內臟功能紊亂。其中脾胃虛寒型胃潰瘍在臨床上比較常見，此類患者病情容易反復，而且在飲食生冷與氣候突變時，容易發作[1]。西醫治療該病具有一定效果，但是不能根治，復發率高，而中醫在治療該病方面效果顯著并且可以有效降低該病的復發率。……