甘氨雙唑鈉對食管鱗癌放射增敏作用的療效分析

[摘要] 目的 探討研究甘氨雙唑鈉對食管鱗癌放射治療增敏作用的臨床療效。方法 方便選取2013年12月—2015年12月平陰縣中醫醫院腫瘤科確診食管癌鱗患者60例。隨機分成觀察組和對照組，每組患者30例，對照組采取單純放療治療，放療總劑量60 Gy/7周，觀察組在常規放療同時使用甘氨雙唑鈉，每2 d使用1次，用藥3次/周，用藥到放射治療過程結束。放療中檢測患者血常規并觀察處理各種不良反應。結果 觀察組完全緩解9例，部分緩解18例，穩定2例，病情惡化1例，總有效率90.00%。對照組患者完全緩解6例，部分緩解14例，穩定8例，病情惡化2例，總有效率66.66%；兩組比較，觀察組的治療效果優于對照組，差異有統計學意義（P<0.05），兩組患者均未發現明顯不良反應。結論 甘氨雙唑對食管鱗癌放療增敏作用確切，且治療安全性好，不良反應小。

[關鍵詞] 食管鱗癌；甘氨雙唑鈉；放射增敏劑

[中圖分類號] R4 [文獻標識碼] A [文章編號] 1674-0742（2016）12（b）-0127-03

Radiosensitization of Esophageal Squamous Cell Carcinoma with Sodium

SUN Xing-liang1， GENG Hai-ying1， SUN Xing-yun2

1.Department of Oncology， Pingyin Traditional Chinese Medicine Hospital，Ji'nan，Shandong Province，250400 China；2.Department of Internal Medicine， Ji'nan Machine Tool Two Factory of Hospital， Ji'nan，Shandong Province，250022 China

[Abstract] Objective To study the effect of sodium glyoxidizine on the radiosensitivity of esophageal squamous cell carcinoma. Methods Convenient selection 60 patients with esophageal squamous cell carcinoma diagnosed by Oncology Department of Pingyin Chinese Medicine Hospital from December 2013 to December 2015， Were randomly divided into observation group and control group， Each group of 30 patients， The control group received radiotherapy alone， the total dose of radiotherapy 60 Gy / 7 weeks， Treatment group in the conventional radiotherapy using glycididazole sodium， used every 2 days， 3 times a week medication， medication to the end of the radiation therapy process. Radiotherapy in patients with blood tests and observe the treatment of various adverse reactions. Results In the treatment group， there were 9 cases of complete remission， 18 cases of partial remission， 2 cases of stabilization， 1 case of exacerbation， the total effective rate was 90.00%. In the control group， complete remission in 6 cases， partial remission in 14 cases， stable in 8 cases， exacerbation in 2 cases， the total effective rate was 66.66%； 2 group compared to the radiotherapy of the treatment group was significantly higher than the control group， The difference was statistically significant （P <0.05）， No significant adverse events were found in either group. Conclusion The effect of glycididazole on radiosensitization of esophageal squamous cell carcinoma is accurate， safe and safe.

[Key words] Esophageal squamous cell carcinoma； Sodium bis； Radiation sensitive agent

食管癌是原發于食管黏膜上皮的惡性腫瘤，我國以鱗狀上皮癌多見，占90%～95%[1]。單純手術切除長期生存率差低。同步放化療雖能降低局部復發率，但不良反應大，對生存率無明顯提高。放射治療治療食道癌的主要方法，研究顯示：實體瘤中存在10%～50%乏氧細胞，對射線產生抗拒，因此降低了放療療效[2]。甘氨雙唑鈉是一種硝基咪唑類化合物，明顯療效的的乏氧細胞增敏劑[2]，能夠增強射線對腫瘤乏氧細胞的破壞作用。對有氧的正常組織細胞損傷較小，且能提高放射治療的臨床療效。方便選取2013年12月—2015年12月該院收治的60例食管鱗癌應用甘氨雙唑鈉聯合放療的效果進行了臨床觀察，現報道如下。……