不同氨溴索給藥方式在新生兒肺炎中的療效對比分析及對肺功能的影響

[摘要] 目的 探討不同氨溴索給藥方式在新生兒肺炎中的臨床治療效果及對肺功能的影響。方法 整群選取2015年5月—2016年7月福建省泉州市泉港區婦幼保健院收治的新生兒肺炎患者105例，隨機分為對照1組（n=35）和對照2組（n=35）和觀察組（n=35）。對照1組采用氨溴索霧化吸入治療，對照2組采用氨溴索靜滴治療，觀察組采用氨溴索霧化吸入聯合靜滴治療，采用肺功能測定儀對患兒治療后肺功能進行測定，比較3組臨床療效及對肺功能的影響。 結果觀察組體溫恢復正常時間（1.5±0.7）d、咳嗽咳痰消失時間（4.1±1.5）d、啰音消失時間（4.3±1.2）d及平均住院時間（5.6±1.1）d，短于對照1組和對照2組，差異有統計學意義（P<0.05）；觀察組治療后肺功能指標：FVC（3.13±0.39）mL、FEV1（2.48±0.51）及FEV水平（78.83±7.25）%，顯著高于對照1組和對照2組，差異有統計學意義（P<0.05）。結論 新生兒肺炎患兒采用氨溴索霧化吸入聯合靜滴治療效果理想，能改善患者肺功能，值得推廣應用。

[關鍵詞] 氨溴索；給藥方式；新生兒肺炎；治療效果；肺功能

[中圖分類號] R4 [文獻標識碼] A [文章編號] 1674-0742（2016）12（b）-0112-03

Effect of Different Ambroxol Administration on Neonatal pneumonia and its Effect on Pulmonary Function

CHEN Ya- bin

Quanzhou City in Fujian Province Spring Harbor Maternal and Child Health Care， Quanzhou， Fujian Province， 362801 China

[Abstract] Objective To discuss the clinical effect of different ambroxol administration in neonatal pneumonia and its effect on pulmonary function. Methods A total of 105 neonatal pneumonia patients were randomly divided into control group 1（n = 35） and control group 2（n = 35） and control group 2（n = 35） from June 2015 to July 2016， in Quanzhou， Fujian province. ） And observation group（n = 35）. The control group 1 was treated with ambroxol inhalation， the control group 2 was treated with ambroxol intravenous drip， and the observation group was treated with ambroxol inhalation combined with intravenous infusion. The lung function test was used to measure the lung function after treatment. The clinical effects and lung function of the three groups were compared. Results The time of recovery of body temperature （1.5 ± 0.7）d， the duration of cough and expectoration （4.1 ± 1.5）d， the time of rale disappearance （4.3 ± 1.2）days and the average length of hospital stay （5.6 ± 1.1）d，FVC （3.13 ± 0.39）mL， FEV1 （2.48 ± 0.51） and FEV （78.83 ± 7.25）% in the control group and the control group， respectively，the difference was not statistically significant（P <0.05）. The pulmonary function indexes of the observation group were significantly higher than those of the control group Group and control group，the difference was not statistically significant（P <0.05）.Conclusion Nebulisation inhalation combined with infusion of ambroxol in children with neonatal pneumonia is ideal and can improve the pulmonary function of patients.

[Key words] Ambroxol； Administration； Neonatal pneumonia； Therapeutic effect； Pulmonary function

新生兒肺炎是新生兒期最為常見的疾病，具有發病率、死亡率高、治愈率高等特點，患兒發病后以彌漫性肺部病變及不典型臨床表現為主要特征，發病早期如果得不到及時有效的治療，將會誘發其他疾病，嚴重者將威脅其生命[1]。目前，臨床上對于新生兒肺炎以氨溴索治療為主，藥物屬于是一種呼吸道潤滑性祛痰劑，能有效的改善患兒癥狀，避免病情進一步發展[2]。但是，氨溴索給藥途徑相對較多，如：霧化吸入、靜滴、聯合用藥等，臨床上對于不同給藥途徑臨床療效尚存在較大的爭議[3]。……