鐘富軍 王麗


摘要:目的 探討老年重癥感染患者診斷中血清降鈣素原(PCT)與C-反應(yīng)蛋白(CRP)聯(lián)合檢測(cè)臨床價(jià)值。方法 選擇80例我院老年重癥感染患者作為觀察組,并以80例老年非感染性患者作為對(duì)照組,采集兩組患者的空腹靜脈血樣,比較兩組患者血清中PCT和CRP的含量及檢測(cè)的陽(yáng)性率等。結(jié)果 觀察組血清中PCT檢測(cè)陽(yáng)性率92.5%,PCT、CRP的平均含量均明顯高于對(duì)照組,差異均具有統(tǒng)計(jì)學(xué)意義(P<0.05);但觀察組CRP陽(yáng)性率與對(duì)照組差異無(wú)統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 PCT特異性較CRP高,穩(wěn)定性較好,PCT和CRP聯(lián)合檢測(cè)可考慮作為老年重癥感染患者嚴(yán)重感染的重要指標(biāo)。
關(guān)鍵詞:血清降鈣素原;C-反應(yīng)蛋白;老年重癥感染
Abstract:Objective To investigate the diagnosis value of serum procalcitonin(PCT)combined with C-reactive protein(CRP)in elderly patients with severe infection.Methods 80 cases of severe infections in elderly patients in our hospital as the observation group,and 80 cases of elderly patients with non-infectious as the control group,two groups of patients collected fasting blood samples were compared in patients with serum content and detect PCT and CRP the positive rate.Results Observer Group in serum PCT positive rate of 92.5%,the average content of PCT(6.31±1.32)ng/ml,the average content of CRP was(40.31±7.23)mg/l,were significantly higher than the 5.0%(0.33±0.08)ng/ml and(5.73±1.12)mg/l,the differences were statistically significant(P<0.05);but positive rate of CRP in observation group and the control group was not statistically significant(P<0.05).Conclusion of PCT has higher specificity and better stability than CRP,PCT combined with CRP can be considered as an important indicator of severe infections in elderly patients with severe infections.
Key words:Serum procalcitonin;C-reactive protein;Elderly patients with severe infection
感染不僅是老年重癥患者最常見(jiàn)的并發(fā)癥,也是造成此類(lèi)老年患者死亡的主要原因[1],對(duì)此類(lèi)患者做出有效預(yù)測(cè),可有效改善患者感染的預(yù)后情況,減少耐藥,提高老年患者生存率。因此,對(duì)老年重癥感染患者采取快速、簡(jiǎn)便的方法檢測(cè)感染,對(duì)于預(yù)防病人發(fā)生感染、改善感染患者的預(yù)后情況等均具有十分重要的意義[2]。臨床上較常使用的感染檢測(cè)指標(biāo)有C-反應(yīng)蛋白(CRP),但其較容易受到其他因素影響[3],相比而言血清降鈣素原(PCT)檢測(cè)的穩(wěn)定性更好。為研究PCT與CRP聯(lián)合檢測(cè)對(duì)于老年重癥感染患者的臨床診斷意義,現(xiàn)選取老年重癥感染患者和同期非感染進(jìn)行血液指標(biāo)調(diào)查,結(jié)果如下報(bào)告。
1 資料與方法
1.1一般資料 隨機(jī)選取2013~2014年我院的老年重癥感染患者80例作為觀察組,感染標(biāo)準(zhǔn)參考2001年衛(wèi)生部頒發(fā)的《醫(yī)院感染診斷標(biāo)準(zhǔn)》[4]為診斷依據(jù),排除:在進(jìn)入外科手術(shù)前既已發(fā)生感染的患者;創(chuàng)傷、燒傷、術(shù)后、嚴(yán)重或長(zhǎng)期的心源性休克者;有急性心肌梗死、惡性腫瘤、嚴(yán)重的肝腎功能損害、活動(dòng)性肺結(jié)核等患者;……