余和晏

摘要:目的 研究并分析治療十二指腸潰瘍出血患者時使用泮托拉唑聯合生長抑素的效果。方法 收集十二指腸潰瘍出血患者共114例,根據隨機分配方案將其分為對照組(57例)和觀察組(57例),對照組的治療藥物為泮托拉唑,觀察組則聯合使用生長抑素,將兩組臨床療效及再出血發生率進行觀察和對比。結果 觀察組的總有效率為94.74%,顯著高于對照組的75.44%,χ2=8.365,P=0.004;觀察組的再出血發生率為3.51%,顯著低于對照組的28.07%,P=0.000。結論 在十二指腸潰瘍出血患者的治療過程中,泮托拉唑聯合生長抑素能夠使患者獲得更佳療效,并顯著降低再出血的發生風險,值得推廣應用。
關鍵詞:十二指腸潰瘍;出血;泮托拉唑;生長抑素;聯合治療;再出血發生率
中圖分類號:R573.1 文獻標識碼:A 文章編號:1006-1959(2017)13-0003-02
Abstract:Objective To study the effect of the treatment of duodenal ulcer and bleeding patients using pantoprazole combined with somatostatin. Methods A total of 114 cases of patients with duodenal ulcer bleeding,according to the random allocation scheme will be divided into control group (57 cases)and observation group(57 cases),the control group was treated with pantoprazole,and the observation group was treated with somatostatin.The clinical efficacy and the rate of rebleeding were observed and compared.Results The total effective rate was 94.74% in the observation group,which was significantly higher than that in the control group,75.44%,χ2=8.365,P=0.004.The incidence of rebleeding in the observation group was 3.51%, which was significantly lower than that in the control group,28.07%,P=0.000.Conclusion Pantoprazole combined with somatostatin can improve the curative effect of patients with duodenal ulcer bleeding and significantly reduce the risk of rebleeding,which is worthy of popularization and application.
Key words:Duodenal ulcer;Bleeding;Pantoprazole;Somatostatin;Combined therapy;Rebleeding rate
十二指腸潰瘍屬于消化性潰瘍的常見病,在冬春兩季好發,且男性的發病率高于女性[1]。相關的研究報道稱,十二指腸潰瘍的發病與幽門螺桿菌感染、胃酸分泌異常、生活飲食不規律、非甾體抗炎藥、吸煙飲酒、工作壓力、精神心理因素等均有著密切的關系[2]。患者在發病時其上腹部會出現疼痛感,表現為劇痛、脹痛、灼痛或鈍痛,該疼痛會呈現節律性,且能夠持續幾周甚至數月。一旦合并出血出現,則具有一定程度的高危性,且患者的病死率較高,因此及時有效的止血治療對于患者預后有著關鍵意義[3]。在本次研究中,對十二指腸潰瘍出血患者采用了泮托拉唑聯合生長抑素的治療方案,現……