蛇毒血凝酶治療肺結核大咯血的臨床效果

陳瓏斌

【摘要】 目的：分析蛇毒血凝酶治療肺結核大咯血的臨床效果。方法：選擇筆者所在醫院收治的82例肺結核大咯血患者，隨機分為兩組，其中常規組患者采取垂體后葉素聯合硝酸甘油進行治療，試驗組患者采取蛇毒血凝酶肌注治療，對比兩組患者的臨床治療效果。結果：試驗組患者的藥物起效時間、咯血消失時間、咯血量均明顯優于常規組，復發率與不良反應發生率均明顯低于常規組，差異均有統計學意義（P<0.05）。結論：對肺結核大咯血患者采取蛇毒血凝酶進行治療的臨床效果顯著，疾病復發率與不良反應發生率均較低，可明顯改善患者臨床癥狀，值得在今后的臨床工作中實踐推廣。

【關鍵詞】 蛇毒血凝酶； 肺結核； 大咯血

doi：10.14033/j.cnki.cfmr.2017.29.010 文獻標識碼 B 文章編號 1674-6805（2017）29-0020-02

Clinical Study on Treatment of Pulmonary Tuberculosis with Hemoptysis by Snake Venom Blood Coagulation Enzyme/CHEN Long-bin.//Chinese and Foreign Medical Research，2017，15（29）：20-21

【Abstract】 Objective：To analyze the clinical efficacy of Snake Venom Blood Coagulation Enzyme in the treatment of massive hemoptysis of pulmonary tuberculosis.Method：Eighty two patients with massive pulmonary tuberculosis were randomly divided into two groups.The patients in the conventional group were treated with Pituitrin combined with Nitroglycerin for the treatment.The patients in the experimental group were treated with Snake Venom Blood Coagulation Enzyme.The clinical treatment effects in two groups were compared.Result：The onset time，time of hemoptysis disappear and amount of hemoptysis were significantly better in the experimental group than those in the conventional group（P<0.05）.The recurrence rate and the incidence of adverse reactions in the experimental group were significantly lower than those in the conventional group，the difference were significant（P<0.05）.Conclusion：The clinical efficacy of Snake Venom Blood Coagulation Enzyme in patients with massive hemoptysis is significant.The recurrence rate of disease and the incidence of adverse reactions are low，which can obviously improve the clinical symptoms of patients，and it is worth practicing in the future clinical practice.

【Key words】 Snake venom blood coagulation enzyme； Tuberculosis； Massive hemoptysis

First-authors address：The Third Hospital of Xiamen City，Xiamen 361000，China

大咯血指的是患者初次咯血量在300 ml以上或者24 h的咯血量在500 ml以上的一類疾病，是肺結核的一類常見并發癥，通常病情較為危急，若不及時采取積極有效的臨床治療方案，將會延誤最佳的疾病治療時機，導致病情進一步發展，引發休克、窒息、繼發感染等不良情況，更有甚者將會死亡[1]。硝酸甘油+垂體后葉素屬于治療肺結核大咯血的常用藥物，但是其弊端在于藥效持續時間較短、起效較慢、容易受到血漿凝血酶的影響[2]。而蛇毒血凝酶屬于一類新興的止血藥物，可達到十分顯著的臨床治療效果。為了對該類疾病患者的治療方案進行更加深入的研究，本文將相關資料分析如下。

1 資料與方法

1.1 一般資料

選擇筆者所在醫院2014年3月-2016年2月收治的82例肺結核大咯血患者作為本次的研究對象，醫護人員同所有患者詳細講解了本次研究的目的、方法、意義等，獲得所有患者的知情同意納入本次研究。……