奧美拉唑與西咪替丁治療應(yīng)激性胃潰瘍的療效觀察

高華初

摘 要：目的 觀察奧美拉唑與西咪替丁治療應(yīng)激性胃潰瘍的臨床效果及對患者生活質(zhì)量的影響。方法 選擇2016年1月～2018年1月我院收治的64例應(yīng)激性胃潰瘍患者，隨機(jī)分為觀察組和對照組，各32例。對照組患者應(yīng)用西咪替丁治療，觀察組應(yīng)用奧美拉唑治療。比較兩組患者的臨床療效、止血時間、胃泌素水平、生活質(zhì)量評分及不良反應(yīng)發(fā)生率。結(jié)果 觀察組患者總有效率為96.88%，高于對照組的78.13%，差異有統(tǒng)計學(xué)意義（P<0.05）；治療后，觀察組患者胃泌素水平低于對照組[（95.24±2.36）pg/ml vs （112.48±2.26）pg/ml] ，差異有統(tǒng)計學(xué)意義（P<0.05）；觀察組患者止血時間短于對照組，且生活質(zhì)量評分高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）；觀察組患者不良反應(yīng)發(fā)生率為3.13%，低于對照組的18.75%，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 對應(yīng)激性胃潰瘍患者實施奧美拉唑的效果較西咪替丁更佳，且更有助于提升患者日常生活質(zhì)量。

關(guān)鍵詞：應(yīng)激性胃潰瘍；奧美拉唑；西咪替丁；生活質(zhì)量

中圖分類號：R573.1 文獻(xiàn)標(biāo)識碼：A DOI：10.3969/j.issn.1006-1959.2018.23.039

文章編號：1006-1959（2018）23-0136-03

Abstract：Objective To observe the clinical effect of Omeprazole and Cimetidine in the treatment of stress gastric ulcer and their effect on the quality of life of patients.Methods 64 patients with stress gastric ulcer from January 2016 to January 2018 were randomly divided into observation group and control group with 32 cases in each group.The control group was treated with Cimetidine and the observation group with Omeprazole.The clinical efficacy， hemostatic time， gastrin level， quality of life score and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 96.88%， which was higher than that in the control group 78.13%，the difference was statistically significant （P<0.05）.After treatment， gastrin levels in the observation group were lower than those in the control group [（95.24 ±2.36） pg/ml vs （112.48 ±2.26） pg/ml]，the difference was statistically significant （P<0.05）.The hemostatic time of the patients in the observation group was shorter than that in the control group， and the score of quality of life in the observation group was higher than that in the control group，the difference was statistically significant （P<0.05）.The incidence of adverse reactions in the observation group was 3.13%， which was significantly lower than that in the control group 18.75%，the difference was statistically significant （P<0.05）.Conclusion The effect of Omeprazole on patients with stress gastric ulcer is better than Cimetidine， and it is more helpful to improve the quality of daily life.

Key words：Stress gastric ulcer；Omeprazole；Cimetidine；Quality of life

應(yīng)激性胃潰瘍（stress gastric ulcer）的患病率呈現(xiàn)逐年增加的趨勢，該疾病屬于臨床常見的消化內(nèi)科疾病之一，具有病情危急、進(jìn)展快速等特點[1]，若治療不及時，患者可出現(xiàn)胃穿孔、休克等并發(fā)癥，嚴(yán)重者可致死，對其生命安全構(gòu)成了嚴(yán)重威脅。因此，對患者實施有效干預(yù)十分關(guān)鍵。藥物療法是治療應(yīng)激性胃潰瘍的有效手段，而如何安全、有效治療應(yīng)激性胃潰瘍已經(jīng)成為臨床關(guān)注的熱點問題，其中奧美拉唑、西咪替丁均屬于臨床治療應(yīng)激性胃潰瘍的常用藥物，但目前臨床關(guān)于上述2種藥物的療效及安全性依然存在一定爭議[2]。為對比奧美拉唑、西咪替丁的臨床療效，我院對應(yīng)激性胃潰瘍患者分別應(yīng)用奧美拉唑、西咪替丁治療，現(xiàn)報道如下。

1 資料與方法

1.1一般資料 選擇2016年1月～2018年1月都昌縣人民醫(yī)院消化內(nèi)科收治的64例應(yīng)激性胃潰瘍患者，按照隨機(jī)數(shù)字表法分為觀察組和對照組，各32例。……