不同促排卵方案治療多囊卵巢綜合征不孕癥的效果

謝丹

摘要：目的 ?觀察不同促排卵方案對(duì)多囊卵巢綜合征不孕癥患者治療效果。方法 ?選擇2018年6月～2019年6月在我院治療的60例多囊卵巢綜合征不孕癥患者，隨機(jī)分為對(duì)照組和實(shí)驗(yàn)組，各30例。對(duì)照組采用人絕經(jīng)期促性腺激素治療，實(shí)驗(yàn)組在對(duì)照組基礎(chǔ)上聯(lián)合應(yīng)用氯米芬治療，比較兩組臨床排卵率、妊娠率、雌二醇水平、黃體生成素水平、子宮內(nèi)膜厚度、成熟卵泡數(shù)及不良反應(yīng)發(fā)生率。結(jié)果 ?實(shí)驗(yàn)組排卵率（86.67%）、妊娠率（36.67%）分別高于對(duì)照組的63.33%、16.67%（P<0.05）;實(shí)驗(yàn)組雌二醇、黃體生成素水平、子宮內(nèi)膜厚度、成熟卵泡數(shù)均高于對(duì)照組（P<0.05）;實(shí)驗(yàn)組不良反應(yīng)發(fā)生率為6.67%，低于對(duì)照組的26.67%（P<0.05）。結(jié)論 ?人絕經(jīng)期促性腺激素聯(lián)合氯米芬治療多囊卵巢綜合征不孕癥療效較好，改善排卵障礙優(yōu)于單用人絕經(jīng)期促性腺激素，有助于提高妊娠率，且臨床不良反應(yīng)發(fā)生率低，安全可行。

關(guān)鍵詞：促排卵;多囊卵巢綜合征;不孕癥

中圖分類(lèi)號(hào)：R711.6 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 文獻(xiàn)標(biāo)識(shí)碼：A ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? DOI：10.3969/j.issn.1006-1959.2020.18.046

文章編號(hào)：1006-1959（2020）18-0141-02

The Effect of Different Ovulation Induction Programs on the Infertility

of Polycystic Ovary Syndrome

XIE Dan

（Department of Obstetrics and Gynecology，Yuecheng Obstetrics and Gynecology Hospital，Jiaxing 314000，Zhejiang，China）

Abstract：Objective ?To observe the effects of different ovulation induction programs on infertility patients with polycystic ovary syndrome.Methods ?A total of 60 infertility patients with polycystic ovary syndrome who were treated in our hospital from June 2018 to June 2019 were selected and randomly divided into a control group and an experimental group， with 30 cases in each group. The control group was treated with human menopausal gonadotropin， and the experimental group was combined with clomiphene treatment on the basis of the control group. The clinical ovulation rate， pregnancy rate， estradiol level， luteinizing hormone level， endometrial thickness， The number of mature follicles and the incidence of adverse reactions.Results ?The ovulation rate （86.67%） and pregnancy rate （36.67%） of the experimental group were higher than those of the control group， 63.33% and 16.67% respectively（P<0.05）; the levels of estradiol and luteinizing hormone in the experimental group endometrial thickness and the number of mature follicles were higher than those of the control group （P<0.05）; the adverse reaction rate of the experimental group was 6.67%， which was lower than 26.67% of the control group（P<0.05）.Conclusion ?The combination of human menopausal gonadotropin combined with clomiphene in the treatment of infertility with polycystic ovary syndrome was effective， and it was better to improve ovulation disorders than using human menopausal gonadotropin alone， which could help increase pregnancy rate and the incidence of clinical adverse reactions was low， safe and feasible.

Key words：Ovulation induction;Polycystic ovary syndrome;Infertility

多囊卵巢綜合征（PCOS）是一種常見(jiàn)的生殖內(nèi)分泌疾病，發(fā)病病因呈多因性，臨床表現(xiàn)呈多態(tài)性的內(nèi)分泌綜合征，是臨床中無(wú)排卵性不孕癥的常見(jiàn)原因。臨床通常給予抗雄激素、藥物誘導(dǎo)等促排卵治療為主，但在臨床促排卵的過(guò)程中，容易發(fā)生黃素化破裂卵泡綜合征以及卵巢過(guò)度刺激綜合征，嚴(yán)重時(shí)會(huì)危及患者的生命安全[1]。然而不同的促排卵方案的效果存在差異，目前臨床尚無(wú)統(tǒng)一的促排卵方案[2]。本研究結(jié)合2018年6月～2019年6月在我院治療的60例多囊卵巢綜合征不孕癥患者臨床資料，分析不同促排卵方案對(duì)多囊卵巢綜合征不孕癥患者治療效果，選擇促排卵方案治療多囊卵巢綜合征提供一定的參考依據(jù)，現(xiàn)報(bào)道如下。

1資料與方法

1.1一般資料 ?選擇2018年6月～2019年6月在浙江省嘉興市悅程婦產(chǎn)醫(yī)院婦產(chǎn)科治療的多囊卵巢綜合征不孕癥患者60例，采用隨機(jī)數(shù)字表法分為對(duì)照組和實(shí)驗(yàn)組，各30例。……