乙型肝炎病毒感染患者發(fā)生原發(fā)性肝癌的影響因素

湯佳媚　周曉玲　沈曉萍　包劍鋒

[關(guān)鍵詞] 乙型肝炎病毒;原發(fā)性肝癌;肝硬化;影響因素;危險因素

[中圖分類號] R735.7? ? ? ? ? [文獻標(biāo)識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）22-0050-04

Impacting factors of primary hepatocellular carcinoma in patients with hepatitis B virus infection

TANG Jiamei1? ?ZHOU Xiaoling1? ?SHEN Xiaoping1? ?BAO Jianfeng2

1.Department of Hepatobiliary and Pancreatic Surgery， Xixi Hospital of Hangzhou， Hangzhou? ?310023， China; 2.Department of Severe Hepatopathy， Xixi Hospital of Hangzhou， Hangzhou? ?310023， China

[Abstract] Objective To investigate the related factors of primary hepatocellular carcinoma（PHC） in patients with hepatitis B virus infection and put forward early preventive measures. Methods PHC patients admitted to and treated in our hospital from January 2017 to December 2020 were selected as the case group（n=316）， and hepatitis B patients without liver cancer in the same period were randomly selected as the control group（n=316）. The differences of factors such as gender， age， body mass index， educational background， long-term smoking history， long-term drinking history， frequency of eating fried food， family history of liver cancer， diabetes， hypertension， liver cirrhosis， fatty liver， no antiviral treatment， hepatitis B virus load， e antigen and frequency of emotional irritability were compared between the two groups. Then， stepwise logistic regression was adopted to screen the related risk factors of PHC in patients with hepatitis B. Results There were statistically significant differences in long-term smoking history， long-term drinking history， frequency of eating fried food， family history of liver cancer， diabetes， liver cirrhosis， fatty liver， no antiviral treatment， hepatitis B virus load， e antigen， frequency of emotional irritability and other factors between the two groups （P<0.05）. The risk factors of PHC impacting patients with hepatitis B included long-term drinking history （OR=4.166）， family history of liver cancer （OR=3.114）， liver cirrhosis （OR=5.436）， fatty liver （OR=3.699）， no antiviral treatment （OR=4.455）， hepatitis B virus load （OR=3.518） and frequency of emotional irritability （OR=2.527）， etc. Conclusion There are many high-risk factors of PHC impacting patients with hepatitis B， so targeted prevention and control should be carried out as soon as possible to reduce the incidence of liver cirrhosis and PHC and improve the prognosis of patients.