阿托伐他汀對(duì)急性心肌梗死患者的心肌保護(hù)作用

[摘要] 目的 探討長期服用阿托伐他汀對(duì)急性心肌梗死患者的心肌保護(hù)作用。 方法 選擇筆者所在醫(yī)院2010年6月～2012年1月收治的急性ST段抬高性心肌梗死患者60例，分為研究組和對(duì)照組，研究組患者連續(xù)服用阿托伐他汀3個(gè)月，對(duì)照組患者采用環(huán)丙貝特治療，隨訪觀察兩組患者發(fā)病時(shí)的肌鈣蛋白及肌酸激酶同工酶的峰值濃度，發(fā)病至峰值時(shí)間、恢復(fù)正常時(shí)間，溶栓治療后血管再通率，患者梗死后心絞痛、心力衰竭、再灌注心律失常發(fā)生率。結(jié)果 研究組血管再通率明顯高于對(duì)照組（P<0.05），梗死后心絞痛、心力衰竭、再灌注心律失常發(fā)生率明顯低于對(duì)照組，研究組肌鈣蛋白、肌酸激酶同工酶峰值濃度及恢復(fù)正常時(shí)間明顯短于對(duì)照組（P<0.05）。 結(jié)論 阿托伐他汀對(duì)心肌梗死具有明顯的保護(hù)作用，可減輕再灌注損傷，增加血管再通率，值得應(yīng)用。

[關(guān)鍵詞] 急性心肌梗死；阿托伐他??；保護(hù)作用

[中圖分類號(hào)] R542.22 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 2095-0616（2012）22-40-03

Myocardial protective effects of Atorvastatin in patients with acute myocardial infarction

SUN Yuexia LU Xiaoqin JIA Zhenlin

Department of Internal Medicine， Hospital of Chinese Medicine of Linzi District in Shandong Province，Zibo 255400，China

[Abstract] Objective To explore Myocardial protective effects of long-term use of atorvastatin in patients with acute myocardial infarction myocardial. Methods 60 patients with acute ST- segment elevation myocardial infarction in our hospital from June 2010 to January 2012 In our hospital were selected and divided into study group（taking atorvastatin for 3 months）and control group（giving ciprofibrate treatment），incidenced of troponin I and creatine kinase isoenzyme peak concentration，the peak time，recovery time，vascular recanalization rate after thrombolytic therapy，postinfarction angina，heart failure，reperfusion arrhythmia incidence were followed up and observed. Results The vascular recanalization rate of study group was significantly higher（P<0.05），postinfarction angina，heart failure，reperfusion arrhythmia incidence was significantly lower than the control group， troponin，creatine kinase isoenzyme peak concentration and the recovery time of study group was significantly shorter than the control group（P<0.05）. Conclusion Atorvastatin has a significant protective effect on myocardial infarction，it can reduce reperfusion injury，increase the recanalization rate，and is worthy of application

[Key words] Acute myocardial infarction；Atorvastatin

急性心肌梗死是指冠狀動(dòng)脈急性閉塞血流中斷所引起局部心肌的缺血性壞死，臨床表現(xiàn)可有持久的胸骨后疼痛、休克、心律失常和心力衰竭，并有血清心肌酶增高以及心電圖的改變。阿托伐他汀能夠降低血漿膽固醇和脂蛋白水平，減少低密度脂蛋白的生成。臨床上用于家族性高膽固醇血癥、混合性高脂血癥等，是臨床應(yīng)用較多的降脂肪藥物，但長期臨床應(yīng)用效果顯示，除了降脂肪作用外，還可以抑制血小板的凝集，維持血管內(nèi)皮的穩(wěn)定，防止血栓形成等[1]。……