曲美他嗪聯合地爾硫卓治療心絞痛的療效

[摘要] 目的 觀察曲美他嗪聯合地爾硫卓治療心絞痛的療效。 方法 選取筆者所在醫院心絞痛患者50例，隨機分為治療組和對照組。對照組給予休息、吸氧、鎮靜、抗凝和抗血小板聚集等常規抗心絞痛處理，治療組在此基礎上，給予口服曲美他嗪片和地爾硫卓片，治療2周后觀察療效和心電圖情況。 結果 治療組總有效率88%，對照組總有效率64%，治療組療效明顯高于對照組，差異有統計學意義（P<0.01）。兩組心電圖改變情況比較，治療組總有效率72%，對照組總有效率52%，治療組心電圖改變情況明顯優于對照組，差異有統計學意義（P<0.01）。治療后，治療組使用硝酸甘油情況明顯較對照組少，差異有統計學意義（P<0.01）。兩組均未發現皮疹等過敏反應，也未發現肝腎功能損害。 結論 在常規治療心絞痛的基礎上，使用曲美他嗪聯合地爾硫卓片治療心絞痛，能夠取得滿意效果，值得臨床推廣。

[關鍵詞] 曲美他嗪；地爾硫卓；心絞痛

[中圖分類號] R541 [文獻標識碼] B [文章編號] 2095-0616（2012）22-70-02

Curative effect of trimetazidine combined with diltiazem for angina

GUO Jinxiang

Department of Internal Medicine， Datong Coal Mine Group Silaogou Mine Hospital， Datong 037028， China

[Abstract] Objective To observe the curative effect of trimetazidine combined with diltiazem for angina. Methods 50 patients with angina were randomly divided into treatment group and control group. The control group was given conventional antianginal treatment， ex rest， oxygen uptake， sedation， anticoagulant and antiplatelet aggregation. The treatment group was given oral trimetazidine and diltiazem tablets on the basis of the control group. The curative effect and ECG information of two groups were observed after 2 weeks. Results The total effective rate of treatment group was 88%， and the total effective rate of control group was 64%. The curative effect of treatment group was obviously higher than that of control group （P<0.01）.On the electrocardiographic changes， the total effective rate of treatment group was 72%，and the total effective rate of control group was 52%.There was significant difference between two groups （P<0.01）.After the treatment， the dosage of nitroglycerin in the treatment group was significantly less than that in the control group （P<0.01）.No allergic reactions（ex skin rash） and liver and kidney function damage in two groups happened. Conclusion On the basis of routine antianginal treatment， trimetazidine combined diltiazem tablets for angina can get satisfactory effect and is worthy of clinical application.

[Key words] Trimetazidine； Diltiazem； Angina

心絞痛是冠狀動脈粥樣硬化引起的血管腔狹窄、阻塞、痙攣，導致心肌發生缺血缺氧，嚴重威脅人類的生命健康。在臨床上，可分為穩定型心絞痛和不穩定型心絞痛，一般通過改善心肌血流，增加氧的供給，減少心梗的發生率，是主要的治療方法。筆者使用曲美他嗪聯合地爾硫卓對心絞痛患者進行治療，效果滿意，現報道如下。

1 資料與方法

1.1 一般資料

選取筆者所在醫院2011年3月～2012年3月收治的心絞痛患者50例，均符合WHO制定的《缺血性心臟病的命名及診斷標準》[1]，隨機分為治療組和對照組，各25例。……