吉西他濱、亞葉酸鈣、氟尿嘧啶聯合治療晚期原發性肝癌32例

[摘要] 目的 分析吉西他濱、亞葉酸鈣、氟尿嘧啶聯合治療晚期原發性肝癌的效果及安全性。 方法 選擇筆者所在醫院32例晚期原發性肝癌患者作為觀察組，采用吉西他濱、亞葉酸鈣、氟尿嘧啶聯合治療；同時選擇同期采用對癥支持治療的32例原發性肝癌患者作為對照組，對兩組患者近期療效與遠期療效進行比較，同時觀察其不良反應。 結果 觀察組近期療效及遠期療效明顯好于對照組，兩組比較差異具有統計學意義（P<0.05）。觀察組患者均能耐受治療，無一例患者因治療相關性死亡，具有較高的安全性。結論 吉西他濱、亞葉酸鈣、氟尿嘧啶聯合治療具有不良反應小，患者耐受性好的優點，可延長患者生存期。

[關鍵詞] 吉西他濱；亞葉酸鈣；氟尿嘧啶；晚期原發性肝癌；效果

[中圖分類號] R735.3 [文獻標識碼] B [文章編號] 2095-0616（2012）22-74-02

Analysis on gemcitabine， calcium folinate combined with fluorouracil on the treatment of 32 patients with advanced primary liver cancer

ZHANG Kangyong WANG Zhifei SUN Fengyan

People's Hospital of Guanyun in Jiangsu Province，Guanyun 222200，China

[Abstract] Objective To analyze the effect and safety of gemcitabine，calcium folinate combined with fluorouracil on the treatment of patients with advanced primary liver cancer. Methods 32 patients with advanced primary liver cancer treated in our hospital were selected as the observation group which were treated with gemcitabine，calcium folinate combined with fluorouracil.32 patients with advanced primary liver cancer applying symptomatic and supportive therapy during the same period were selected as the control group. Comparing the curative effect in the near future and the long term effect between 2 groups， and observing the adverse reactions. Results The curative effect in the near future and of the observation group were better than that of the control group， which had statistical significance（P<0.05）.The patients in the observation group all could tolerate the treatment and there was no treatment-related deaths，which had high security. Conclusion The treatment of gemcitabine，calcium folinate combined with fluorouracil has the advantages of fewer adverse reactions and good tolerance for patients and can prolong the survival period of patients.

[Key words] Gemcitabine；Calcium folinate；Fluorouracil；Advanced primary liver cancer；Effect

據WHO和我國衛生部調查顯示，我國是世界上癌癥發病率和死亡率較高的國家之一[1]，而在各器官癌癥中，肝癌屬于發病率較高的癌癥之一，尤其是原發性肝癌由于早期無明顯癥狀，以致于難以診斷從而導致治療滯后[2]，明確診斷時往往已是腫瘤晚期，已失去了手術治療的機會，只能通過保守治療與對癥支持治療來緩解癥狀，延長生存期，因此，原發性肝癌死亡率極高。本研究采用吉西他濱、亞葉酸鈣、氟尿嘧啶聯合化療，取得了滿意的效果，現報道如下。

1 資料與方法

1.1 一般資料

選擇筆者所在醫院2008年6月～2011年6月32例晚期原發性肝癌患者作為觀察組，采用吉西他濱、亞葉酸鈣、氟尿嘧啶聯合治療；……