三磷酸胞苷加地塞米松等綜合治療突發性耳聾的療效分析

余朝陽+錢學貞

[摘要] 目的 探討三磷酸胞苷加地塞米松等綜合治療突發性耳聾的效果。 方法 以我院2008年8月～2013年8月間收治的122例突發性耳聾患者為研究對象，隨機分為觀察組與對照組，對照組采用常規療法，觀察組采用三磷酸胞苷加地塞米松等的綜合治療，比較兩組患者臨床治療效果、臨床癥狀恢復情況、治療期心理健康水平和生活質量之間的差異。 結果 觀察組患者治療效果優于對照組，臨床癥狀輕于對照組，治療期間心理健康水平和生活質量高于對照組，差異有統計學意義（P < 0.05）。 結論 使用三磷酸胞苷加地塞米松等綜合治療突發性耳聾可以取得滿意效果，其可以提高臨床治療效果、改善患者臨床癥狀、提高患者治療期生活質量和心理健康程度。

[關鍵詞] 突發性耳聾；三磷酸胞苷；地塞米松

[中圖分類號] R764.43 [文獻標識碼] B [文章編號] 1673-9701（2014）02-0054-03

Efficacy of cytidine triphosphate combined with dexamethasone comprehensive treatment for sudden deafness

YU Zhaoyang QIAN Xuezhen

Department of ENT， Songgang People's Hospital of Baoan District Shenzhen City in Guangdong Province， Shenzhen 518105， China

[Abstract] Objective To investigate the efficacy of cytidine triphosphate combined with dexamethasone comprehensive treatment for sudden deafness. Methods A total of 122 cases with sudden deafness admitted in our hospital from August 2008 to August 2013 were selected as the research objects， who were randomly divided into the observation group and the control group. The patients in the control group were treated with the conventional therapy， while the patients in the observation group were treated with cytidine triphosphate combined with dexamethasone comprehensive treatment. The clinical therapeutic effect， clinical symptoms recovery， mental health level and quality of life during the treatment period of patients in the two groups were compared. Results The therapeutic effect of patients in the observation group was better than that in the control group， and the clinical symptoms was lighter， and the mental health level and quality of life during the treatment period were higher， and the difference was statistically significant（P < 0.05）. Conclusion Cytidine triphosphate combined with dexamethasone comprehensive treatment for sudden deafness can achieve satisfactory effect， improve the clinical treatment effect， improve the clinical symptoms of patients， and increase the mental health level and quality of life during the treatment period.

[Key words] Sudden deafness； Cytidine triphosphate； Dexamethasone

突發性耳聾（sudden deafness，SD）是耳科常見急癥之一，在各年齡層中均有一定發病率，會給患者帶來極大的心理恐慌，甚至發生繼發性傷害[1]。目前，對于SD的發病機制尚未完整闡述[2]，只是推斷其是一種感音神經性聾，在發病初級幾分鐘之內即可達到高峰[3]。現階段在臨床上對于SD的治療主要以藥物為主[4]，但效果并不明確。本文以我院2008年8月～2013年8月收治的突發性耳聾患者122例為研究對象，就三磷酸胞苷加地塞米松等綜合治療突發性耳聾的療效進行研究，現報道如下。

1 資料與方法

1.1 一般資料

選擇我院2008年8月～2013年8月間收治的122例突發性耳聾患者，其中男91例，女31例，患者年齡20～65歲，平均（45.95±9.27）歲，所有患者均因突然非波動性聽力減退伴或不伴有耳鳴、暈眩等癥狀入院，且排除患有蝸窗破裂及內聽道占位性疾病，經臨床檢查，所有患者均明確診斷患有SD，符合1997年中華醫學會耳鼻咽喉科學會制定的《突發性耳聾診斷及療效分級標準》，患者從發病到治療平均時間（17.58±5.94）h。……