聯合綜合心理干預對復發性抑郁癥患者抑郁情緒、生命健康質量及神經遞質的影響

唐文娟+錢一平+顧康瑩

[摘要] 目的 探討聯合綜合心理干預對復發性抑郁癥患者抑郁情緒、生命健康質量及神經遞質的影響。 方法 收集2014年4月～2015年6月在江蘇省淮安市第三人民醫院進行住院治療的復發性抑郁癥患者80例，按照隨機數字表法分為對照組（40例）、觀察組（40例）。對照組患者接受常規干預，觀察組患者接受常規干預聯合綜合心理干預。比較兩組患者抑郁情緒評分、生命健康質量評分及血清單胺類神經遞質含量。 結果 干預前，兩組抑郁情緒、生命健康質量評分，血清中單胺類神經遞質含量差異無統計學意義（P > 0.05）。干預后，觀察組抑郁情緒評分低于對照組，生命健康質量評分高于對照組，觀察組患者血清中去甲腎上腺素、五羥色胺、多巴胺的含量高于對照組患者（P < 0.05）。 結論 綜合心理干預可緩解復發性抑郁癥患者的抑郁情緒，提升生命質量。

[關鍵詞] 復發性抑郁癥；綜合心理干預；抑郁情緒；生命健康質量；神經遞質

[中圖分類號] R473 [文獻標識碼] A [文章編號] 1673-7210（2017）12（a）-0170-04

[Abstract] Objective To study the influence of comprehensive psychological intervention on depressive mood， life health quality and neurotransmitter in patients with recurrent depression. Methods From April 2014 to June 2015， 80 patients with recurrent depression in the Third People's Hospital of Huai'an City were divided into control group （40 cases） and observation group （40 cases） by random number table. Patients in the control group were treated with routine clinical intervention， while those in observation group were treated with comprehensive psychological intervention combined with routine clinical intervention. The scores of depressive and life quality and the serum content of monoamine neurotransmitter in the two groups were compared. Results Before the intervention， there were no significant differences in the scores of depressive and life quality and the serum content of monoamine neurotransmitter between the two groups （P > 0.05）. After intervention， the scores of depressive in the observation group were lower than those in the control group， the scores of life quality in the observation group were higher than those in control group， the levels of NE， 5-HT， DA in the observation group were higher than those in control group （P < 0.05）. Conclusion Comprehensive psychological intervention can relieve depression and improve the quality of life in patients with recurrent depression.

[Key words] Recurrent depression； Comprehensive psychological intervention； Depressive mood； Life health quality； Neurotransmitter

復發性抑郁癥是指抑郁發作次數≥2次的抑郁癥類型，臨床認為此類患者需接受長期治療以避免抑郁再次發作[1-2]。復發性抑郁癥患者的抑郁心境、認知障礙等均較首發患者嚴重，臨床治療及干預的難度也增加，需加入針對性干預促使以徹底緩解患者病情。復發性抑郁癥患者由于病情反復發作，患者及家屬失去信心和耐心，對患者的理解、支持不足，導致患者病情進一步加重，影響其預后，需同時對家屬也進行針對性干預，讓患者很好地配合治療；抗抑郁藥物仍然是復發性抑郁癥患者治療的最主要方式，但越來越多的研究指出，心理認知障礙在抑郁癥發生發展中扮演重要角色，舒緩患者的負面情緒、建立正確認知、鼓勵患者重新融入社會是最為關鍵的“非藥物治療措施”[3]。本次……