尤瑞克林聯合醒腦靜治療急性腦梗塞對患者神經功能的影響

郭靖　安曉雷　李曉賓　歐春影　許可

[摘要] 目的 分析尤瑞克林聯合醒腦靜治療急性腦梗塞對患者神經功能的影響。 方法 方便選擇2017年2月—2018年2月，醫院神經內科收治的急性腦梗塞患者80例，按照入院順序分組，對照組、觀察組各入組40例，均給予基礎抗血小板、降血脂等基礎治療，對照組尤瑞克林，觀察組聯合醒腦靜。 結果 觀察組2周后、8周后、卒中90 d的NIHSS評分分別為（6.3±1.2）分、（4.0±2.1）分、（1.9±1.1）分低于對照組（7.7±1.5）分、（5.5±1.7）分、（3.1±1.0）分，差異有統計學意義（t=4.609、3.511、5.105，P=0.000、0.001、0.000<0.05）。觀察組與對照組2周后LPA分別為（2.2±0.7）μmol/L、（2.8±0.8）μmol/L低于治療前（3.7±1.1）μmol/L、（3.6±1.3）μmol/L（t=7.266、3.315，P=0.000、0.001）、觀察組低于對照組（t=3.570、P=0.001），觀察組與對照組卒中90 d的認知功能量表評分分別為（27.4±2.6）分、（25.0±4.1）分高于2周時（24.1±2.4）分、（22.3±2.0）分（t=5.899、3.743，P=0.000、0.000）、觀察組高于對照組（t=3.127、0.002），差異有統計學意義（P<0.05）。觀察組認知、精神相關并發癥發生率15.0%低于對照組37.5%，差異有統計學意義（χ2=5.230，P=0.022<0.05）。結論尤瑞克林聯合醒腦靜治療急性腦梗塞可以減輕神經功能損傷。

[關鍵詞] 急性腦梗塞;神經功能;尤瑞克林;醒腦靜

[中圖分類號] R743.3? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-0742（2019）07（a）-0106-03

Effect of Ureklin Combined with Xingnaojing on Neurological Function in Patients with Acute Cerebral Infarction

GUO Jing， AN Xiao-lei， LI Xiao-bin， OU Chun-ying， XU Ke

Department of Neurology， Xuzhou Central Hospital， Xuzhou， Jiangsu Province， 221000 China

[Abstract] Objective To analyze the effect of Ureklin combined with Xingnaojing on the neurological function of patients with acute cerebral infarction. Methods From February 2017 to February 2018， 80 patients with acute cerebral infarction admitted to the Department of Neurology of the hospital were convenient divided into two groups according to the order of admission. The control group and the observation group were each enrolled of 40 cases， all of which were given basic antiplatelet and blood lipid lowering treatment， the control group of Ureklin， the observation group combined with awakening brain. Results The NIHSS scores of the observation group were （6.3±1.2）points， （4.0±2.1）points， and （1.9±1.1）points lower than the control group （7.7±1.5）points， （5.5±1.7）points， （3.1±1.0） points after 2 weeks， 8 weeks， and 90 days of stroke， the difference was statistically significant （t=4.609， 3.511， 5.105， P=0.000， 0.001， 0.000<0.05）. After 2 weeks in the observation group and the control group， LPA was （2.2±0.7） μmol/L and （2.8±0.8） μmol/L， respectively， lower than （3.7±1.1） μmol/L and （3.6±1.3） μmol/L before treatment （t=7.266， 3.315， P=0.000， 0.001）， the observation group was lower than the control group （t=3.570， P=0.001）， and the cognitive function scale scores of the observation group and the control group were 90 days （27.4±2.6）points，（25.0±4.1）points points higher than 2 weeks （24.1 ± 2.4） points， （22.3±2.0） points （t=5.899， 3.743， P=0.000， 0.000）， the observation group was higher than the control group （t=3.127， 0.002）， the difference was statistically significant （P<0.05）. The incidence of cognitive and mental-related complications in the observation group was 15.0% lower than that in the control group （37.5%）， and the difference was statistically significant （χ2=5.230， P=0.022<0.05）. Conclusion Ureklin combined with Xingnaojing can reduce neurological damage by treating acute cerebral infarction.