關節腔內注射玻璃酸鈉治療類風濕關節炎的療效觀察

周燕莉 王焰

【摘要】 目的 探討類風濕關節炎應用關節腔內注射治療的臨床效果。方法 100例類風濕關節炎患者， 隨機分為關節腔內注射治療組和常規治療組， 每組50例。常規治療組給予甲氨蝶呤治療， 關節腔內注射治療組在常規治療組基礎上給予關節腔內注射玻璃酸鈉治療。觀察比較兩組治療前后關節視覺模擬評分、晨僵維持時間、腫脹程度評分、C反應蛋白、血沉、疼痛癥狀消失時間、疼痛癥狀緩解時間以及不良反應發生情況。結果 治療后， 關節腔內注射治療組關節視覺模擬評分（1.24±0.15）分、晨僵維持時間（1.24±0.12）h、腫脹程度（5.53±1.01）分、C反應蛋白（10.19±2.36）μg/L、血沉（34.56±3.26）mm/h均低于常規治療組的（3.24±1.34）分、（1.78±0.61）h、（6.56±1.42）分、（14.11±4.12）μg/L、（45.72±12.11）mm/h， 差異具有統計學意義（P<0.05）;關節腔內注射治療組疼痛癥狀消失時間、疼痛癥狀緩解時間分別為（42.12±3.57）、（12.12±3.21）d， 明顯短于常規治療組的（57.57±3.89）、（18.57±3.24）d， 差異有統計學意義（P<0.05）。兩組不良反應發生率比較， 差異無統計學意義（P>0.05）。結論 類風濕關節炎患者實施關節腔內注射玻璃酸鈉治療可獲得較好效果。

【關鍵詞】 類風濕關節炎;關節腔內注射;玻璃酸鈉

DOI：10.14163/j.cnki.11-5547/r.2019.29.037

【Abstract】 Objective? ?To discuss the clinical effect of intra-articular injection of sodium hyaluronate for the treatment of rheumatoid arthritis. Methods? ?A total of 100 rheumatoid arthritis patients were randomly divided into intra-articular injection group and conventional treatment group， with 50 cases in each group. The conventional treatment group received methotrexate for treatment， and the intra-articular injection group received intra-articular injection of sodium hyaluronate on the basis of the conventional treatment group. Observation and comparison were made on visual analogue score of joint， duration of morning stiffness， degree of swelling， C-reactive protein， erythrocyte sedimentation rate before and after treatment， disappearance time of pain symptoms， remission time of pain symptoms and occurrence of adverse reactions between the two groups. Results? ?After treatment， the visual analogue score of joint （1.24±0.15） points， duration of morning stiffness （1.24±0.12） h， duration of morning stiffness （5.53±1.01） points， C-reactive protein （10.19±2.36） μg/L and erythrocyte sedimentation rate （34.56±3.26） mm/h in the intra-articular injection group were lower than （3.24±1.34） points， （1.78±0.61） h， （6.56±1.42） points， （14.11±4.12） μg/L and （45.72±12.11） mm/h in the conventional treatment group. Their difference was statistically significant （P<0.05）. The disappearance time of pain symptoms and remission time of pain symptoms respectively as （42.12±3.57） and （12.12±3.21） d in the intra-articular injection group， and that were obviously shorter than （57.57±3.89） and （18.57±3.24） d in conventional treatment group. Their difference was statistically significant （P<0.05）. There was no statistically significant difference in incidence of adverse reactions between the two groups （P>0.05）. Conclusion? ?Intra-articular injection of sodium hyaluronate in rheumatoid arthritis patients can achieve better results.