謝世宇 程賢高 丁丹
摘 要:目的 通過對我院近4年來150例PICU危重患兒的病例進行剖析,總結影響預后的相關因素。方法 收集150例2014年3月~2018年5月于我院PICU住院治療危重患兒的臨床資料作為研究對象,按預后不同,分為生存組97例和終點事件組53例,對比兩組患兒在降鈣素原、乳酸脫氫酶、血鈣、血乳酸及血 pH 值水平的差異。結果 兩組患兒的年齡和性別比較,差異無統計學意義(P>0.05)。生存組患兒降鈣素原、乳酸脫氫酶和血乳酸分別為(0.72±0.31)ng/ml、(75.43±28.88)IU/L和(4.71±1.88)mmol/L,均低于終點事件組的(1.98±0.92)ng/ml、(119.2±49.89)IU/L和(8.46±2.98)mmol/L;血鈣和血pH值分別為(1.41±0.55)mmol/L和(7.23±0.20),高于終點事件組的(1.13±0.42)mmol/L和(7.05±0.15),差異均具有統計學意義(P<0.05)。結論 對于降鈣素原、乳酸脫氫酶、血乳酸明顯升高,血鈣值低和嚴重酸中毒患兒,生存質量及預后差,死亡風險上升,這些臨床指標對PICU危重患兒預后具有重要的臨床指導意義。
關鍵詞:危重癥;預后;危險因素;兒童
中圖分類號:R720.597 文獻標識碼:A DOI:10.3969/j.issn.1006-1959.2018.22.029
文章編號:1006-1959(2018)22-0107-03
Analysis of Prognostic Risk Factors in Critically Ill Children with PICU
XIE Shi-yu,CHENG Xian-gao,DING Dan
(Department of Pediatrics,Anqing Hospital Affiliated to Medical University Of Anhui,Anqing 246000,Anhui,China)
Abstract:Objective To analyze the related factors affecting prognosis by analyzing 150 cases of PICU critically ill children in our hospital in the past 4 years.Methods A total of 150 patients with critically ill children who were hospitalized in our hospital from March 2014 to May 2018 were enrolled as the study subjects. According to the prognosis, they were divided into the survival group of 97 cases and the end point group of 53 cases. Differences in procalcitonin, lactate dehydrogenase, serum calcium, blood lactate, and blood pH levels.ResultsThere was no significant difference in age and gender between the two groups (P>0.05). Procalcitonin, lactate dehydrogenase and blood lactate in the survival group were(0.72±0.31) ng/ml, (75.43±28.88) IU/L and (4.71±1.88) mmol/L, respectively, which were lower than the endpointgroup (1.98±0.92) ng/ml, (119.2±49.89) IU/L and (8.46±2.98) mmol/L; the serum calcium and blood pH values were (1.41±0.55) mmol/L and (7.23±0.20), respectively, above the endpoint group (1.13 ± 0.42) mmol/L and(7.05±0.15), the difference was statistically significant(P<0.05). Conclusion For procalcitonin, lactate dehydrogenase, blood lactate, blood calcium and severe acidosis, the quality of life and prognosis are poor, and the risk of death increases. These clinical indicators have important clinical guiding significance for the prognosis of critically ill children with PICU.
Key words:Critical illness;Prognosis;Risk factors;Children
兒童是國家的未來,兒童健康應當引起全社會的重點關注。隨著醫療技術的逐步發展,全國各地區相繼建立了適合兒童急救條件的重癥監護病房,有利于提高患兒的治愈率。但我國各地區經濟和醫療水平存在一定的差異,尤其小兒疾病具備進展迅速、死亡率高的特點,相對落后地區的兒童生存質量仍偏低,因而臨床工作者合理評價預后風險因素,積極采取高效救治措施是患兒病情轉歸及預后的關鍵。近年來,已有研究報道危重患兒預后的相關危險因素[1-3],本研究就我院150例PICU危重患兒在降鈣素原、乳酸脫氫酶、血鈣、血乳酸和血pH值生化指標中進行探討,現報道如下。
1資料與方法
1.1一般資料 選取2014年3月~2018 年5月安徽醫科大學附屬安慶醫院PICU住院并滿足危重病例標準的150例患兒,本研究經醫院倫理會批準。按……