左乙拉西坦對癲癇患兒骨代謝與認知功能的影響

周定富 王萍 何穎慧

【摘要】 目的：研究和分析左乙拉西坦對癲癇患兒骨代謝和認知功能的具體影響。方法：選取2017年8月-2019年8月筆者所在醫(yī)院收治的80例癲癇患兒作為本次研究觀察的對象，通過隨機數(shù)表法將所有癲癇患兒分為對照組和試驗組，每組40例。對照組患兒在常規(guī)的醫(yī)療護理基礎(chǔ)上使用丙戊酸鈉藥物治療，試驗組在常規(guī)的醫(yī)療護理基礎(chǔ)上使用左乙拉西坦藥物治療，對比分析兩組癲癇患兒治療前后的DQ評分、治療后的癲癇發(fā)作情況、骨代謝和維生素D代謝情況。結(jié)果：試驗組治療后的DQ評分更高，血清中的25-（OH）D3的水平更高（P<0.05）;試驗組癲癇發(fā)作率低于對照組，但比較差異無統(tǒng)計學(xué)意義（P>0.05）。結(jié)論：左乙拉西坦藥物治療對癲癇患兒骨代謝影響較小，提高患兒的認知功能，且癲癇發(fā)作率不高，其安全性高，值得在臨床癲癇治療過程中廣泛應(yīng)用。

【關(guān)鍵詞】 左乙拉西坦 丙戊酸 癲癇 骨代謝 認知功能 治療效果

[Abstract] Objective： To study and analyze the specific effects of levetiracetam on bone metabolism and cognitive function in children with epilepsy. Method： Eighty children with epilepsy admitted to our hospital from August 2017 to August 2019 were selected as the subjects of this study. All children with epilepsy were divided into control group and experimental group by random number table method， 40 cases in each group. The children in the control group were treated with Sodium Valproate on the basis of routine medical care. The experimental group was treated with Levetiracetam on the basis of routine medical care. The DQ scores of the children with epilepsy before and after treatment， seizures after treatment， bone metabolism and vitamin D metabolism were compared and analyzed. Result： The DQ scores of the children of the study group was higher， and the level of 25-（OH）D3 in serum of the study group was higher （P<0.05）. The attack rate of the experimental group was lower than that of the control group， but there was not significant difference （P>0.05）. Conclusion： Levetiracetam drug therapy can reduce the seizures of children with epilepsy， and improve the cognitive function of children with epilepsy and has high safety. It is worthy of widespread application in clinic on the epilepsy treatment.

兒科臨床醫(yī)學(xué)中，癲癇是最為常見的神經(jīng)系統(tǒng)慢性疾病。發(fā)病高峰期往往是在兒童十歲以下，癲癇的病理因素是兒童的大腦內(nèi)部神經(jīng)元群之間發(fā)生間歇性失調(diào)、紊亂、異常放電等，發(fā)病時患兒往往表現(xiàn)出抽搐、驚厥等臨床特征[1]。由于兒童的器官發(fā)育不完全，所以如果不采取相關(guān)治療措施控制病情，會導(dǎo)致患兒的神經(jīng)元群受損，造成患兒的永久智力障礙[2]。由此可見，癲癇對患兒的身體健康和未來發(fā)展有巨大影響。做好癲癇疾病的防治工作具有重大的現(xiàn)實意義和價值。本文通過研究筆者所在醫(yī)院收治的80例癲癇患兒利用不同藥物治療，對比分析了不同藥物的療效和對患兒骨代謝、認知功能的影響，報道如下。……