吳堅平 楊立榮
摘 要:生物制造手性化學品是以生物學、化學、工程學及信息學等學科的交叉為手段,以光學純化學品的高質量合成為目標,以快速、高效、高選擇性和綠色為特征,以蛋白結構分析、分子生物學、合成生物學、化學合成和反應工程學及系統工程理論等為手段,為手性化學品的清潔、高效、經濟和快速生產提供創造性設計思想和新型科學方法。通過分子理性設計、反應性能強化和制造系統重構,最終實現手性化學品的高效綠色生物制造。
關鍵詞:生物制造 手性化學品 理性設計 性能強化 系統重構 綠色制造 高效
Abstract:Bio-manufacturing of chiral chemicals uses the cross means of biology, chemistry, engineering and informatics. It focuses on the high quality synthesis of optical pure chemicals, in a quick, efficient, high selective and green way. Based on the analysis of protein structure, molecular biology, synthetic biology, chemical synthesis, reaction engineering and system engineering, it provides creative design thinkings and new scientific methods for the clean, efficient, economic and fast production of chiral chemicals. Through rational design, reaction performance enhancement and reconstruction of manufacturing systems, the efficiency green-manufacturing of chiral chemicals will be realized.
Key Words:Bio-manufacturing;Chiral chemicals;Rational design;Performance enhancement;System reconstruction;Green-manufacturing;High efficiency
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